Caffeine Increases Core Temperature without Altering Markers of Kidney or Gut Injury after Physical Work in the Heat in Caffeine-Habituated Adults
Specht JW, Ramirez MR, Quintana A, Bailly AR, Peña A, Schmidt E, DE Castro Magalhães F, McKenna ZJ, Schlader ZJ, Amorim FT
Medicine and science in sports and exercise · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of New Mexico
- Universidad u hospital
- University of New Mexico’s Graduate and Professional Student Association
Según 2 financiadores declarados.
Publicación
- Publicado
- 2026-03-03 · Med Sci Sports Exerc · vol. 58 · número 7 · págs. 1493–1506
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 0 citas · más que el 13% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thermoregulation and physiological responses · Coffee research and impacts · Exercise and Physiological Responses
- Palabras clave
- caffeine, core body temperature, acute kidney injury, intestinal injury, endotoxemia, heat stress, cystatin C, urinary biomarkers, heat acclimation, fluid loss, heart rate, exercise in the heat, intestinal permeability, neutrophil gelatinase-associated lipocalin, TIMP-2
- MeSH
- humans, endotoxemia, caffeine, body temperature, cross-over studies, double-blind method, heart rate, adult, female, male, hot temperature, young adult, acute kidney injury, biomarkers
10 autores
- Jonathan W. Specht🇺🇸 · autor de correspondenciaUniversity of Northern Iowa; University of New Mexico
- Marissa Ramirez🇺🇸University of New Mexico
- Amber Quintana🇺🇸University of New Mexico
- Alyssa R. Bailly🇺🇸University of New Mexico
- Ariel Pena🇺🇸University of New Mexico
- Ethan Schmidt🇺🇸University of New Mexico
- Flávio de Castro Magalhães🇺🇸University of New Mexico
- Zachary J. McKenna🇺🇸University of Arkansas at Fayetteville
- Zachary J. Schlader🇺🇸Indiana University Bloomington; Indiana University
- Fabiano Trigueiro Amorim🇺🇸University of New Mexico
Resumen
El texto original del estudio, en el idioma en que se publicó.
Methods
Using a double-blind, crossover design, 14 (6 male) active, caffeine-habituated adults ingested 5 mg/kg of bodyweight (up to 400 mg) of caffeine or placebo 30 min before a 2-h heat trial (35°C dry bulb, 50% relative humidity) involving walking (40% peak) and box-lifting. Bodyweight was measured pre- and post-trial. Core temperature (Tcore) and heart rate (HR) were recorded every 10 min. Blood and urine samples were collected pre-, post-, and 1-h post-trial to assess markers of AKI, intestinal injury, and endotoxemia.
Results
Caffeine increased peak Tcore (38.2 ± 0.4 vs 38.0 ± 0.3°C; P = 0.02), peak HR (147 ± 18 vs 138 ± 17 bpm; P = 0.02), and bodyweight loss (1.7% ± 1.0% vs 1.5% ± 1.1%, P = 0.04) compared with placebo. There were no differences in markers of AKI (urinary insulin-like growth factor-binding protein 7• tissue inhibitor of metalloproteinase 2, neutrophil gelatinase-associated lipocalin) ( P > 0.05). Serum cystatin C increased from pre- to post-trial in the caffeine (∆0.24 ± 0.43 mg/L, P = 0.03) but not placebo (∆-0.07 ± 0.17 mg/L, P = 0.81) condition, suggesting a reduction in glomerular filtration. There were no differences in markers of intestinal injury (intestinal fatty acid binding protein) or endotoxemia (lipopolysaccharide-binding protein, soluble cluster of differentiation 14) ( P > 0.05).
Conclusions
Caffeine ingestion before work in the heat exacerbated increases in Tcore but did not affect biomarkers of kidney or intestinal injury. Workers performing labor in hot environmental conditions should consider that caffeine during work in the heat may increase the rate of Tcore rise.
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