Vitamin D Status and Supplementation in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
Huang S, Li X, Wu H, Chen X, Wu X, Huang Z, Chang L, Zhang Y, Li Y, Zhang G
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Guangdong Province
- Gobierno
- Guangzhou Municipal Science and Technology Project
- Subvenciones
- Natural Science Foundation of Guangdong Province (2023A1515012430); Guangzhou Municipal Science and Technology Project (2023A03J0208); National Natural Science Foundation of China (82271145); National Natural Science Foundation of China (82101196：82101194); National Natural Science Foundation of China (82301283)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2026-03-03 · Otolaryngol Head Neck Surg · vol. 174 · número 5 · págs. 1135–1145
- Editorial
- Wiley
- Citado
- 1 cita · más que el 85% de estudios similares · 3.4× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sinusitis and nasal conditions · Vitamin D Research Studies · Salivary Gland Disorders and Functions
- Palabras clave
- Vitamin D and neurology, Disease, vitamin D deficiency, Clinical trial, Diabetes mellitus
- MeSH
- humans, chronic disease, vitamins, vitamin d, dietary supplements, rhinosinusitis
10 autores
- ShuYi Huang🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- X. Li🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Haotian Wu🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Xiaohong Chen🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Xifu Wu🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Zizhen Huang🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Lu Chang🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Y Zhang🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Yong Li🇨🇳Sun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- GeHua Zhang🇨🇳 · autor de correspondenciaSun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To investigate the relationship between vitamin D (VD) levels and chronic rhinosinusitis (CRS), and to evaluate the therapeutic efficacy of VD supplementation for CRS.
Data sources
Two independent reviewers systematically searched PubMed, Embase, and the Cochrane Library to identify studies that assessed the association between CRS and VD, as well as the therapeutic effects of VD supplementation on CRS outcomes.
Review methods
Meta-analyses were conducted to compare VD levels between CRS patients and controls and to evaluate the efficacy of VD supplementation. Random- or fixed-effects models were applied as appropriate. Sensitivity and subgroup analyses were performed to investigate potential sources of heterogeneity.
Results
A pooled analysis of 15 studies showed significantly lower serum VD levels in CRS patients compared to controls (SMD = -0.98; P < .001). Both 25(OH)D3 and 25(OH)D assays showed lower VD levels in CRS patients (SMD = -1.24, P < .001 vs SMD = -0.77, P < .001). Subgroup analyses also revealed consistent reductions in both CRS with nasal polyps (CRSwNP; SMD = -1.05; P < .001) and CRS without nasal polyps (CRSsNP; SMD = -1.02; P < .001). Moreover, four randomized controlled trials indicated that VD supplementation significantly improved Sino-Nasal Outcome Test-22 (SNOT-22) scores at <3 months (MD = -1.44; P = .001); however, this benefit was not maintained at ≥3 months (MD = -6.52; P = .12).
Conclusions
CRS patients show significantly lower serum VD levels than healthy controls. VD supplementation may provide short-term symptomatic improvement, although its long-term efficacy remains unproven.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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