The effects of time-restricted eating on energy balance regulation in adults with overweight/obesity and type 2 diabetes
Kramer CK, Zinman B, Feig DS, Retnakaran R
International journal of obesity (2005) · 3 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-03-11 · Int J Obes (Lond) · vol. 50 · número 6 · págs. 1228–1235
- Editorial
- Springer Nature
- Citado
- 3 citas · más que el 98% de estudios similares · 12.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Regulation of Appetite and Obesity · Bariatric Surgery and Outcomes
- Palabras clave
- time-restricted eating, energy balance, leptin, ghrelin, peptide YY, glucagon-like peptide-1, glucagon, type 2 diabetes, obesity, overweight, weight loss, fasting blood glucose, appetite regulation, glucose tolerance, lipolysis, ketogenesis, caloric deficit, macronutrient distribution
- MeSH
- humans, diabetes mellitus, type 2, obesity, weight loss, peptide yy, leptin, blood glucose, glucose tolerance test, fasting, cross-over studies, energy metabolism, energy intake, adult, middle aged, female, male, overweight, glucagon-like peptide 1, ghrelin, intermittent fasting
4 autores
- Caroline Kaercher Kramer🇨🇦 · autor de correspondenciaMount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute
- Bernard Zinman🇨🇦Mount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute
- Denice S. Feig🇨🇦Mount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute
- Ravi R. Retnakaran🇨🇦Mount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
Time-restricted eating (TRE) induces a metabolic shift in substrate utilization increasing lipolysis and ketogenesis. These metabolic changes raise the possibility of a differential effect on energy balance regulation following TRE-induced weight loss. The aim of this study is to evaluate the impact of TRE on energy balance homeostasis in individuals with overweight/obesity and type 2 diabetes (T2DM) who participated in a recently reported trial achieving substantial weight reduction (-3.86% body weight).
Subjects/methods
In this randomized cross-over trial, 39 participants with overweight/obesity and T2DM were randomized to either 6 weeks of TRE (20 h fasting/4 h eating) or standard lifestyle, followed by 4-week washout and then the other dietary intervention for 6 weeks. At each study visit at baseline, 6-, 10-, and 16-week participants completed a 75 g oral glucose tolerance test (OGTT). We measured fasting and post-challenge responses of glucose, glucagon, GLP-1, ghrelin, leptin, and peptide YY.
Results
TRE-induced calorie deficit as participants self-reported ingested -384 ± 488 Kcal/day less during TRE as compared to the standard lifestyle period (P 0-120 min 0.04 ± 23.5, P = 0.99), GLP-1 (AUC0-120 min 1.6 ± 67.6, P = 0.98), ghrelin (AUC0-120 min 31.0 ± 32.4, P = 0.35), and peptide YY (AUC0-120 min -33.9 ± 65.6, P = 0.61). Importantly, TRE-induced weight loss promoted a significant decrease in both fasting leptin (-2445 ± 885 ng/mL, P = 0.009) and leptin response to OGTT (AUC0-120 min -12776 ± 3088, P < 0.001) as compared to standard lifestyle. In addition, a significant increase in fasting ghrelin (28 ± 11.3 pg/mL, P = 0.02) was observed post-TRE as compared to pre-intervention.
Conclusions
These findings demonstrate that TRE does not prevent the physiologic compensatory changes associated with weight reduction in individuals with overweight/obesity and T2DM.
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