A proprietary herbal extract of ashwagandha root for stress and anxiety in healthy adults: a randomized, double-blind, three-arm, placebo-controlled efficacy and safety study
West RE, Biswas A, Rao R, Tayade H, Ademola J
Journal of medicine and life · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-01-01 · J Med Life · vol. 19 · número 1 · págs. 49–62
- Editorial
- Carol Davila University of Medicine and Pharmacy Publishing House
- Citado
- 0 citas · más que el 16% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Medicinal Plant Extracts Effects · Medicinal Plants and Neuroprotection
- Palabras clave
- ashwagandha root, Withania somnifera, plant extracts, stress, anxiety, healthy adults, efficacy, safety
- MeSH
- humans, withania, plant roots, hydrocortisone, plant extracts, double-blind method, stress, psychological, anxiety, adolescent, adult, aged, middle aged, female, male, young adult
5 autores
- Rahul Rao🇮🇳Bharati Vidyapeeth (Deemed to be University)
- Rogene Eichler West
- Anima Biswas
- Himanshu Tayade🇮🇳D.Y. Patil University
- John Ademola
Resumen
El texto original del estudio, en el idioma en que se publicó.
Stress and anxiety are interconnected, sharing both behavioural and neural foundations. Ashwagandha (Withania somnifera) helps reduce stress and anxiety. This study aimed to evaluate the efficacy and safety of a proprietary herbal extract of ashwagandha root (APB) in adult men and women with moderate stress and anxiety. This 8-week, randomized, double-blind, three-arm, placebo-controlled trial included 141 healthy men and women aged 18-65 years with stress and anxiety. Participants were randomized to receive either 300 mg of APB twice daily (n = 47), ashwagandha root extract (ARE, n = 47), or placebo (PL, n = 47) for 8 weeks. The primary endpoint was a change in serum cortisol levels at week 8. Secondary endpoints were the mean changes in Perceived Stress Scale (PSS), Hamilton Anxiety Rating Scale (HAM-A), Profile of Mood States (POMS), and Oxford Happiness Questionnaire (OHQ) scores. Safety was assessed through clinical adverse events (AEs) and laboratory parameters. Between-group comparisons were analyzed using one-way ANOVA with Tukey's post-hoc test, and within-group changes were assessed using paired t-tests. At 8 weeks, all groups have shown a significant reduction in serum cortisol, and improvements in PSS (P P = 0.001), and POMS domain scores (tension, depression, and anger, P P < 0.05). The proprietary herbal extract of ashwagandha root (300mg twice daily) is considered an effective and safe intervention for reducing stress and anxiety.
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