Omega-3 fatty acids and tear cytokines modulation in dry eye patients with low omega-3 index. Have the beneficiaries been pinpointed?
Gupta K, Bathla N, Pawaiya S, Mehta B, Badgujar P, Bhargava R, Juyal S
Indian journal of ophthalmology · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-03-12 · Indian J Ophthalmol · vol. 74 · número 7 · págs. 1033–1039
- Editorial
- Medknow
- Citado
- 2 citas · más que el 98% de estudios similares · 12.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 20 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY-NC-ND
- Áreas de investigación
- Ocular Surface and Contact Lens · Fatty Acid Research and Health · Retinal Diseases and Treatments
- Palabras clave
- omega-3 fatty acids, dry eye, omega-3 index, tear cytokines, eicosapentaenoic acid, docosahexaenoic acid, anti-inflammatory supplementation, interleukins, TNF-α, goblet cell density, tear film break-up time, Schirmer test, imprint cytology
- MeSH
- tears, humans, dry eye syndromes, fatty acids, omega-3, cytokines, treatment outcome, follow-up studies, double-blind method, dietary supplements, adult, middle aged, female, male
7 autores
- Kriti Gupta
- Nisha Bathla
- Shikha Pawaiya
- Bhavya Mehta
- Pooja Badgujar
- Rahul Bhargava · autor de correspondencia
- Smiti Juyal
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To assess the impact of omega-3 fatty acid (O3FA) supplements on tear inflammatory cytokines in dry eye patients with an omega-3 index below 4%.
Methods
This randomized controlled study involved 102 dry eye patients with an omega-3 index below 4%. Participants received either four capsules of O3FAs (325 mg eicosapentaenoic acid, 175 mg docosahexaenoic acid) or a placebo containing olive oil twice daily for 6 months. Patients were evaluated at baseline and 1, 3, and 6 months. The primary outcome measured changes in tear cytokines (IL-1β, IL2, IL4, IL5, IL6, IL8, IL10, IF-γ, and TNF-α). Secondary outcomes included improvements in dry eye symptoms, Nelson grade, goblet cell density, Schirmer test values, and tear film breakup time. Group means (pretreatment, 1, 3, and 6 months) were compared using repeated measure analysis of variance.
Results
At baseline, impression cytology revealed that mRNA levels of IL-1β, IL-6, IL-8, and TNF-α were elevated by 1.6- to 2.4-fold in the O3FA group and 1.74 to 2.6-fold in the placebo group ( P = 0.123). The O3FA group experienced a statistically significant reduction ( P < 0.05) in tear cytokines. This group showed a 60% increase in the omega-3 index at 6 months, indicating high adherence to treatment. The dry eye symptom score, goblet cell density, and Nelson grade improved significantly in the O3FA group. However, these changes were not significant in the placebo group.
Conclusion
This study underscores the potential advantages of O3FA supplementation in decreasing tear inflammatory cytokines in dry eye patients with an omega-3 index below 4%.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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