Effects of Sauna bathing on Exercise Capacity and Muscle Function in HFpEF
Bekfani T, Abo Hwach A, Moebert R, Seibel S, Burger A, Kaehne T, M Bekhite M, Vargas KG, Janashia M, Groscheck T, Daboul A, Rauwolf T, Behrendt T, Lichtenauer M, Paar V, Lemmer P, Friede T, Schega L, Biering-Sorensen T, Schulze PC, Anker SD, von Haehling S, Schmeisser A, Braun-Dullaeus RC
European journal of heart failure · 0 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- department of Cardiology, Angiology, and Intensive Medicine, University Hospital Magdeburg
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-03-12 · Eur J Heart Fail
- Editorial
- Elsevier BV
- Citado
- 3 citas · más que el 100% de estudios similares · 35.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Cardiovascular and exercise physiology · Cardiovascular Function and Risk Factors · Nutrition and Health in Aging
- Palabras clave
- Anaerobic exercise, Heart failure, Heart failure with preserved ejection fraction, Heart rate, Exercise intolerance, Skeletal muscle, Ejection fraction, Blood pressure, Cardiac function curve
24 autores
- Tarek Bekfani🇩🇰🇩🇪 · autor de correspondenciaUniversity of Copenhagen; University Hospital Magdeburg
- Ammar Abo Hwach🇩🇪University Hospital Magdeburg
- R Moebert🇩🇪University Hospital Magdeburg
- S Seibel🇩🇪University Hospital Magdeburg
- Alina Burger🇩🇪University Hospital Magdeburg
- Thilo Kaehne🇩🇪Otto-von-Guericke-Universität Magdeburg
- Mohamed M. Bekhite🇩🇪Jena University Hospital; Friedrich Schiller University Jena
- Kris Gregory Vargas🇩🇪University Hospital Magdeburg
- M Janashia🇩🇪University Hospital Magdeburg
- Thomas Groscheck🇩🇪University Hospital Magdeburg
- Alaa Daboul🇩🇪University Hospital Magdeburg
- Thomas Rauwolf🇩🇪University Hospital Magdeburg
- Tom Behrendt🇩🇪Otto-von-Guericke-Universität Magdeburg
- Michael Lichtenauer🇦🇹Paracelsus Medical University
- Vera Paar🇦🇹Paracelsus Medical University
- Peter Lemmer🇩🇪University Hospital Magdeburg
- Tim Friede🇩🇪German Centre for Cardiovascular Research
- Lutz Schega🇩🇪Otto-von-Guericke-Universität Magdeburg
- Tor Biering-Sorensen🇩🇰University of Copenhagen
- P Christian Schulze🇩🇪Jena University Hospital; Friedrich Schiller University Jena
- Stefan D Anker🇩🇪Berlin-Brandenburger Centrum für Regenerative Therapien; German Centre for Cardiovascular Research; Berlin Institute of Health at Charité - Universitätsmedizin Berlin
- Stephan von Haehling🇩🇪German Centre for Cardiovascular Research
- Alexander Schmeisser🇩🇪University Hospital Magdeburg
- R C Braun-Dullaeus🇩🇪University Hospital Magdeburg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Treatment options to improve exercise capacity in heart failure with preserved ejection fraction (HFpEF) are limited. We hypothesized that sauna bathing enhances exercise performance, skeletal muscle function, body composition, and quality of life (QoL) in HFpEF. However, benefits may decline after discontinuation. SAUNA-HFpEF is the first prospective mechanistic, translational pilot study investigating feasibility, safety, and efficacy of supervised sauna bathing in stable HFpEF outpatients.
Methods
Participants completed 10 weeks of sauna sessions (60°C, twice weekly), with duration progressively increased from 8 to 15 minutes. Blood pressure and heart rate were monitored three times per session. Assessments were performed at baseline, end of study (after 10 weeks intervention), and 3 months after sauna withdrawal (follow-up), including echocardiography, cardiopulmonary exercise testing, 6-minute walk test (6MWT), quadriceps strength testing, QoL questionnaires (SF-36, HADS, EQ-5D), laboratory testing, and body composition. Skeletal muscle biopsies were collected at baseline and at end of study to explore structural and metabolic mechanisms.
Results
Eighteen patients completed the study with 97% adherence and no adverse events. Peak VO2 and 6MWT improved [(18.2±5.1 to 20.6±5.7 ml/min/kg, p<0.001), 494±95 to 527±111m (p=0.006)], as did anaerobic threshold, quadriceps strength, diastolic function (E/e´), HADS-depression-score, and SF-36 social functioning; p<0.05). At follow-up, peak VO2 and anaerobic threshold declined compared to end of study (p<0.01). Body fat mass decreased continuously. Muscle biopsies showed anabolic/metabolic upregulation and catabolism downregulation.
Conclusion
Sauna bathing was safe, feasible, and improved exercise capacity, body composition, muscle function, and QoL in HFpEF. Benefits diminished after withdrawal. A large multicentre controlled randomized trial is currently being planned.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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