Association of Lp(a) with coronary plaque burden and high-risk plaque features: A meta-analysis of imaging studies
Sebastian SA, Bimal T, Ayyalu T, Vartak N, Bhatia HS, Tsimikas S
Atherosclerosis · 6 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL170224); National Heart, Lung, and Blood Institute (K08HL166962); National Heart, Lung, and Blood Institute (R01HL159156)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2026-03-13 · Atherosclerosis · vol. 415 · pág. 120706
- Editorial
- Elsevier BV
- Citado
- 6 citas · más que el 99% de estudios similares · 12.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Cardiac Imaging and Diagnostics · Lipoproteins and Cardiovascular Health · Coronary Interventions and Diagnostics
- Palabras clave
- lipoprotein(a), coronary plaque, plaque burden, plaque progression, low-attenuation plaque, plaque rupture risk, percent atheroma volume, coronary CT angiography, intravascular ultrasound, optical coherence tomography, cardiovascular risk markers
- MeSH
- coronary vessels, humans, disease progression, lipoprotein(a), coronary angiography, tomography, optical coherence, ultrasonography, interventional, risk assessment, risk factors, aged, middle aged, female, male, coronary artery disease, plaque, atherosclerotic, biomarkers, computed tomography angiography
6 autores
- Sneha Annie Sebastian🇺🇸 · autor de correspondenciaAugusta University Health
- Tia Bimal🇺🇸Icahn School of Medicine at Mount Sinai
- Tanesh Ayyalu🇺🇸Saint Vincent Hospital
- Natasha Vartak🇺🇸Northwell Health
- Harpreet Singh Bhatia🇺🇸University of California San Diego
- Sotirios Tsimikas🇺🇸University of California San Diego
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular disease, but its impact on long-term coronary plaque progression remains unclear. This study synthesizes evidence from CCTA, IVUS, and OCT to clarify the relationship between high-risk Lp(a) and coronary plaque burden and high-risk plaque features.
Methods
We conducted a comprehensive search of multiple databases up to July 2025 for studies evaluating Lp(a) and atherosclerotic plaque progression. Statistical analysis was performed using a random-effects model in RevMan 5.4, reporting odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CI). The protocol is registered in PROSPERO (CRD420251113955).
Results
Our final analysis included 16 studies comprising 19,822 participants with a mean age of 62 years and a median imaging follow-up ranging from 10 months to 10.2 years. On analysis, high-risk Lp(a) levels were significantly associated with the presence of coronary plaque (OR 1.53; 95% CI, 1.03-2.29; p = 0.04) compared with low Lp(a) levels. Additionally, patients with elevated Lp(a) exhibited significantly greater progression in percent atheroma volume (ΔPAV) than those with low levels (MD 4.31%; 95% CI, 1.08-7.53; p = 0.009). Subgroup analysis by plaque phenotype revealed a statistically significant increase in low-attenuation plaque (LAP) presence among individuals in the high-risk Lp(a) category (OR 1.92; 95% CI, 1.13-3.27; p = 0.02).
Conclusion
High-risk Lp(a) is associated with greater coronary plaque prevalence, accelerated progression, and increased LAP. These findings underscore Lp(a) as a driver of high-risk, rupture-prone plaques and a critical biomarker and potential therapeutic target in cardiovascular risk management.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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