Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients With a History of Myocardial Infarction: A Randomized-Controlled Crossover Study
Los J, Broeders W, Bahrar H, Bulut Ö, Bekkering S, den Boeft A, Sumpter N, Cetinyurek-Yavuz A, Hol IH, Netea MG, Cornel JH, El Messaoudi S, Riksen NP
Journal of the American Heart Association · 3 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Dutch Cardiovascular Alliance
- Gobierno
- ZonMw
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-03-20 · J Am Heart Assoc · vol. 15 · número 8 · pág. e048092
- Editorial
- Wiley
- Citado
- 3 citas · más que el 98% de estudios similares · 12.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Gut microbiota and health
- Palabras clave
- time-restricted eating, myocardial infarction, systemic inflammation, innate immunity, neutrophils, neutrophil-to-lymphocyte ratio, monocytes, CD11b expression, metabolomics, coronary artery disease, dietary intervention, cardiovascular risk
- MeSH
- neutrophils, humans, myocardial infarction, inflammation, prospective studies, cross-over studies, time factors, aged, middle aged, female, male, immunity, innate, intermittent fasting
13 autores
- Jonathan Los🇳🇱Radboud University Medical Center
- Wieteke Broeders🇳🇱Radboud University Medical Center
- Harsh Bahrar🇳🇱Radboud University Medical Center
- Ozlem Pinar Bulut🇳🇱Radboud University Medical Center
- Siroon Bekkering🇳🇱Radboud University Medical Center
- Andrea den Boeft🇳🇱Radboud University Medical Center
- Nicholas A. Sumpter🇳🇱Radboud University Medical Center
- Aysun Cetinyurek‐Yavuz🇳🇱Radboud University Medical Center
- Ilse H. Hol🇳🇱Radboud University Medical Center
- Mihai G. Netea🇳🇱Radboud University Medical Center
- Jan Hein Cornel🇳🇱Radboud University Medical Center; Werkgroep Cardiologische centra Nederland
- Saloua El Messaoudi🇳🇱Radboud University Medical Center
- Niels Peter Riksen🇳🇱 · autor de correspondenciaRadboud University Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Preclinical evidence suggests that time-restricted eating (TRE) exerts beneficial metabolic and cardiovascular effects by ameliorating inflammation and modulating immune cell function. However, the effect in patients with established coronary artery disease remains unknown.
Methods
In this prospective, randomized, open-label, blinded end point crossover study, we explored the effect of a 2-week TRE intervention (eating allowed between 8 am and 2 pm) on metabolomic parameters, innate immune cell function, and systemic inflammation in patients with a history of myocardial infarction. Patients were randomized to a 2-week TRE intervention or a 2-week control period with their regular diet, followed by a ≥6-week washout and crossover to the other group. Blood samples were collected in a fasted state before and after each period.
Results
In total, 19 patients (mean age, 65.3 years [SD 8.1], 2 [11%] female), of whom 10 were randomized to start with the control diet, and 9 randomized to start with the TRE diet, were included in the current analysis. All visits were conducted between November 2022 and January 2024. Compared with the control diet, the TRE diet led to reduced neutrophil counts, lower neutrophil-to-lymphocyte ratio, decreased neutrophil CD11b expression, and anti-inflammatory changes in the monocyte transcriptome. Furthermore, a reduction in low-grade systemic inflammation was found. The TRE diet was associated with widespread metabolic changes. No significant effects on monocyte subsets, monocyte inflammatory surface marker expression, or cytokine production capacity were observed.
Conclusions
Our findings highlight the capability of TRE in the modulation of inflammation, suggesting a potential role in reducing cardiovascular risk in patients with established cardiovascular disease.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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