Meta-analysis of the efficacy of interventions for persons living with Alzheimer's disease: The role of music therapy
Zhou C, Ji Y, Wang Y, Liang Y, Cao Y, Lin L, Wang Y, Yang Z, Liu S, Chen H
Journal of Alzheimer's disease : JAD · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Tianjin Scientific Research Projects in Key Areas of Traditional Chinese Medicine
- Subvenciones
- National Natural Science Foundation of China (82171182)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2026-03-23 · J Alzheimers Dis · vol. 111 · número 2 · págs. 505–517
- Editorial
- IOS Press
- Citado
- 0 citas · más que el 12% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Music Therapy and Health · Dementia and Cognitive Impairment Research · Music Education and Analysis
- Palabras clave
- music therapy, Alzheimer's disease
- MeSH
- humans, alzheimer disease, treatment outcome, music therapy, quality of life, caregivers, randomized controlled trials as topic
10 autores
- Chaohui Zhou🇨🇳Tianjin Medical University
- Yong Ji🇨🇳Tianjin Huanhu Hospital; Tianjin Medical University
- Yanchun Wang🇨🇳Tianjin Medical University
- Yun Liang🇨🇳Tianjin Huanhu Hospital; Tianjin Medical University
- Yu Cao🇨🇳Tianjin Medical University
- Lijun Lin🇨🇳Tianjin Medical University
- Yucan Wang🇨🇳Tianjin Medical University
- Zhen Yang🇨🇳Tianjin Medical University
- Shuai Liu🇨🇳Tianjin Huanhu Hospital; Tianjin Medical University
- Hui Chen🇨🇳 · autor de correspondenciaTianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
BackgroundEmerging evidence supports the clinical utility of music therapy for Alzheimer's disease (AD), yet robust clinical evidence remains limited.ObjectiveThis study aimed to systematically evaluate the multidimensional effects of music therapy on individuals with AD and to identify optimal intervention parameters and cumulative duration thresholds to guide clinical implementation.MethodsWe conducted a systematic review using RevMan 5.4, analyzing 24 randomized controlled trials (n = 2316) from Chinese and English databases up to January 2025.ResultsCompared to controls, music therapy significantly improved cognition (MD = 2.14, 95%CI = 0.88∼3.41, p = 0.0009), reduced neuropsychiatric symptoms (SMD = -0.55, 95%CI = -0.99∼-0.12, p = 0.01) and anxiety (MD = -4.37, 95%CI = -6.68∼-2.06, p = 0.0002), enhanced quality of life (SMD = 0.51, 95%CI = 0.02∼1.01, p = 0.04), and alleviated caregiver burden (SMD = -0.75, 95%CI = -0.94∼-0.55, p 3 sessions/week (p = 0.002), duration <40 min/session (p = 0.03), and intervention period ≥12 weeks (p = 0.002). A staged care model progressing from individual to group-based approaches is recommended (all p < 0.05). Minimum cumulative intervention durations for symptom improvement were: ≥1440 min for quality of life, ≥1800 min for behavioral and psychological symptoms, and ≥3360 min for cognition (all p < 0.05).ConclusionsMusic therapy demonstrates multidimensional benefits for persons living with AD, with distinct cumulative dose thresholds required for improving specific clinical symptoms, providing valuable guidance for clinical practice.
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