Optimal dosage of exercise combined with intermittent fasting for body composition and cardiometabolic health in adults: a systematic review and multilevel meta-analysis
Jiao M, Yan H, Zhang B, Zhao X, Li J, Harun MT
Frontiers in nutrition · 0 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-03-10 · Front Nutr · vol. 13 · pág. 1772836
- Editorial
- Frontiers Media
- Citado
- 0 citas · más que el 10% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 146 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Cardiovascular and exercise physiology · Physical Activity and Health
- Palabras clave
- physical activity, intermittent fasting, body composition, cardiometabolic health, muscle performance, insulin resistance, visceral fat, fat-free mass, cardiorespiratory fitness, exercise dose, weight loss, obesity, lipid profile, glycemic control, VO2max
6 autores
- Mingyue Jiao🇨🇳Hezhou University
- Henghao Yan🇨🇳Southwest University
- Binbin Zhang🇲🇾🇨🇳 · autor de correspondenciaINTI International University; Guangdong Ocean University
- Xiaohui Zhao🇨🇳Hezhou University
- Jian Li🇲🇾🇨🇳INTI International University; Shanxi Institute of Science and Technology
- Mohd Taib Harun🇲🇾INTI International University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This meta-analysis evaluated the effects of exercise combined with intermittent fasting (EX + IF) on body composition, cardiometabolic health, and muscle performance in adults and examined potential moderators. (2) PubMed, Web of Science, Embase, and the Cochrane Library were searched, and reference lists of eligible studies were screened. Effect sizes were calculated as Hedges'g. A three-level random-effects model was fitted using the metafor package in R, with moderation and meta-regression analyses conducted to identify influential factors.
Results
Sixty-five randomized controlled trials (RCTs) including 3,293 participants (18-75 years) were included; 42% were overweight/obese and 11% were trained individuals. Compared with control conditions (exercise alone, intermittent fasting alone, or neither), EX + IF significantly reduced body mass, body mass index, body fat percentage, fat mass, waist circumference, and visceral fat, with no significant effects on fat-free mass or lean body mass. For cardiometabolic outcomes, EX + IF reduced total cholesterol, triglycerides, low-density lipoprotein cholesterol, and interleukin-6; improved fasting blood glucose, fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR); and modestly increased VO2max. Multivariable meta-regression indicated maximal effects with 45-60 min per session, 4 sessions/week (230-300 min/week), over 14-30 weeks (cumulative training time 7,463-8,592 min).
Conclusion
EX + IF improves body composition in adults, benefits selected lipid and glycemic markers, and enhances cardiorespiratory fitness. Based on current evidence, it may be particularly suitable for middle-aged adults with overweight/obesity whose primary goals are weight loss and improved insulin resistance (45-60 min/session, 4 sessions/week, for ≥14 weeks).
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD420251131430.
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