The Effect of Vitamin D3 Supplementation on Vitamin D Status and Associated Health Outcomes in Children: A Randomized Controlled Trial
Royle E, Glatt DU, McSorley EM, Pourshahidi K, Armstrong DJ, Grimley L, Slevin MM, Henry CO, McMullan JE, Iniesta RR, McCluskey JT, Gleeson N, Magee PJ
The Journal of nutrition · 0 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Queen Margaret University
- Gobierno
- Department for the Economy
- Gobierno
- Northern Ireland Department for the Economy
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-03-24 · J Nutr · vol. 156 · número 8 · pág. 101493
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 18% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Vitamin K Research Studies
- Palabras clave
- vitamin D3 supplementation, vitamin D status, 25-hydroxyvitamin D, vitamin D deficiency, children, grip strength, balance, cognitive function, immunological markers, bone turnover markers
- MeSH
- humans, vitamin d deficiency, cholecalciferol, vitamin d, hand strength, double-blind method, cognition, seasons, nutritional status, dietary supplements, child, child, preschool, ireland, female, male, biomarkers, united kingdom
13 autores
- Emily Royle🇬🇧University of Ulster
- Dominique Ulrike Glatt🇬🇧University of Ulster
- Emeir M. McSorley🇬🇧University of Ulster
- L. Kirsty Pourshahidi🇬🇧University of Ulster
- David Armstrong🇬🇧Altnagelvin Area Hospital; Western Health and Social Care Trust
- Laura Grimley🇬🇧University of Ulster
- Mary M. Slevin🇬🇧University of Ulster
- Cealan O. Henry🇬🇧University of Ulster
- James E McMullan🇬🇧University of Ulster
- Raquel Revuelta Iniesta🇬🇧University of Exeter
- Jane T. McCluskey🇬🇧Queen Margaret University
- Nigel Gleeson🇬🇧Queen Margaret University
- Pamela Jane Magee🇬🇧 · autor de correspondenciaUniversity of Ulster
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D is a key regulator of musculoskeletal growth, immune regulation, and cognitive function in children. As children in the United Kingdom (UK) and Ireland are at risk of vitamin D deficiency due to the northern latitude, supplementation is recommended. To our knowledge, the effect of supplementation on status and related health outcomes has not been investigated in children residing in the UK/Ireland.
Objectives
To examine the effect of vitamin D3 supplementation on vitamin D status and related health outcomes in children.
Methods
The D vitamin in children study was a double-blind, randomized, placebo-controlled trial, conducted among healthy children (aged 4-11 y). Children received 12 wk of either 10 μg/d vitamin D3 or a placebo devoid of vitamin D (control) in the form of an oral spray. The primary outcome, plasma 25-hydroxyvitamin D, and secondary outcomes, including grip strength, balance, cognitive function, winter status, immune markers, and bone turnover markers, were assessed pre- and postintervention.
Results
One hundred eighteen participants completed the study (mean age 8.1 ± 1.8 y; 51% girls). Supplementation significantly increased 25-hydroxyvitamin D concentration (from 66.31 ± 17.26 nmol/L to 69.04 ± 16.93 nmol/L) compared to a decline in the placebo group (63.67 ± 19.48 nmol/L to 56.29 ± 18.58 nmol/L; P < 0.001) and prevented deficiency during the extended winter months. No effects were observed on muscle function, cognitive function, immune function, or bone turnover markers.
Conclusions
Vitamin D insufficiency is prevalent in UK/Irish children, and supplementation in the form of an oral spray is effective in achieving/maintaining an adequate status in most children. Further research is warranted to elucidate mechanisms underpinning nonresponse to supplementation and to further investigate the potential beneficial effects of supplementation on cognitive function. This trial was registered at clinicaltrials.gov as NCT05018988.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.