Time-restricted eating for body weight management in women with polycystic ovary syndrome: a randomized controlled trial
Corapi S, Runchey MC, Lyons J, Alonso de Leon M, Pavlou V, Lin S, Ezpeleta M, Gabel K, Tussing-Humphreys L, Oddo VM, Alexandria SJ, Sanchez J, Vidmar AP, Varady KA, Cienfuegos S
Nature medicine · 1 cita
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-03-27 · Nat Med · vol. 32 · número 6 · págs. 2155–2163
- Editorial
- Nature Portfolio
- Citado
- 5 citas · más que el 99% de estudios similares · 19.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Ovarian function and disorders · Eating Disorders and Behaviors
- Palabras clave
- time-restricted eating, polycystic ovary syndrome, weight loss, caloric restriction, weight management, women, meal timing, weight loss resistance
- MeSH
- humans, polycystic ovary syndrome, body weight, weight loss, caloric restriction, adult, female, young adult, intermittent fasting
15 autores
- Sarah Corapi🇺🇸University of Illinois Chicago
- Mary-Claire Runchey🇺🇸University of Illinois Chicago
- Jodie Lyons🇺🇸University of Illinois Chicago
- Maria Alonso de Leon🇺🇸University of Illinois Chicago
- Vasiliki Pavlou🇺🇸University of Illinois Chicago
- Shuhao Lin🇺🇸University of Illinois Chicago
- Mark Ezpeleta🇺🇸University of Illinois Chicago
- Kelsey Gabel🇺🇸University of Illinois Chicago
- Lisa Marie Tussing-Humphreys🇺🇸University of Illinois Chicago
- Vanessa M. Oddo🇺🇸University of Illinois Chicago
- Shaina J. Alexandria🇺🇸Northwestern University
- Julienne Sánchez🇺🇸University of Illinois Chicago
- Alaina P. Vidmar🇺🇸University of Southern California
- Krista A Varady🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago
- Sofia Cienfuegos🇺🇸University of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Polycystic ovary syndrome (PCOS) is an endocrinological disorder characterized by weight-loss resistance. Time-restricted eating (TRE) has become a popular weight-loss tool. However, the efficacy of TRE for weight management in PCOS remains understudied. We evaluated the effectiveness of TRE compared with standard care (daily calorie restriction (CR)) and a no-intervention control in women with PCOS. Seventy-six participants were randomly assigned to one of three groups for 6 months: a 6-hour TRE regimen (all meals consumed between 1 p.m. and 7 p.m., without calorie tracking), a CR plan (25% daily energy restriction) or a control group with no dietary changes. The primary endpoint was percent change in body weight at 6 months. By month 6, body weight significantly decreased in the TRE group (-4.32% (95% CI, -6.20, -2.44), P < 0.01) and the CR group (-4.66% (95% CI, -7.13, -2.19), P < 0.01), relative to controls, with no difference between the TRE and CR groups (0.34% (95% CI, -2.15, 2.83), P = 0.79). No serious adverse events were reported. Our results show that in women with PCOS, TRE induced greater weight loss than the controls and was comparable to that achieved with daily CR. ClinicalTrials.gov registration: NCT05629858 .
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