Clinical evidence for the adaptogenic effects of <i>Withania somnifera</i> and <i>Rhodiola rosea</i> - A systematic review with molecular interpretation of psychometric outcomes
Łuszczak J, Kocki J
Annals of agricultural and environmental medicine : AAEM · 1 cita
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-12-09 · Ann Agric Environ Med · vol. 33 · número 1 · págs. 3–11
- Editorial
- Institute of Rural Health
- Citado
- 1 cita · más que el 37% de estudios similares · 0.1× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Medicinal Plants and Bioactive Compounds · Phytochemicals and Medicinal Plants · Andrographolide Research and Applications
- Palabras clave
- Interpretation (philosophy), MEDLINE, Psychometrics, Reliability (semiconductor), Cognition
- MeSH
- humans, rhodiola, withania, plant extracts, stress, psychological, psychometrics, randomized controlled trials as topic
2 autores
- Joanna Łuszczak🇵🇱 · autor de correspondenciaMedical University of Lublin
- Janusz Kocki🇵🇱Medical University of Lublin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction and objective
Adaptogens are plant-derived substances that enhance the body's resilience to physical and psychological stress, with Withania somnifera and Rhodiola rosea being among the most studied representatives. The aim of this review is to evaluate the adaptogenic effects of W. somnifera and R. rosea based on randomized controlled trials (RCTs).
Review methods
A systematic literature search was performed using the key words: 'ashwagandha', 'Withania somnifera', 'Rhodiola rosea', and 'plant adaptogen'. Twenty-four studies met the inclusion criteria - 19 on W. somnifera and 5 on R. rosea.
Brief description of the state of knowledge
The analyzed trials involved 10-590 participants, aged 18-75 years, both healthy individuals and patients with stress-related or functional disorders. Interventions included standardized extracts at daily doses of 120-1000 mg for W. somnifera and 290-1500 mg for R. rosea, with supplementation lasting 3-16 weeks. Reported benefits included reduction of stress and anxiety, alleviation of depressive symptoms, improved sleep quality, enhancement of cognitive functions, increased muscle strength and recovery, and favourable hormonal changes. Methodological heterogeneity, short intervention periods, and small sample sizes remain limitations.
Summary
Evidence from RCTs confirms that W. somnifera and R. rosea exert multi-dimensional adaptogenic effects, improving psychophysical health and supporting stress resilience. Their mechanisms involve regulation of the hypothalamic-pituitary-adrenal axis, neurotransmission, immune and hormonal pathways. Further long-term, high-quality clinical trials, supplemented with molecular and systemic approaches, are required to consolidate their role in integrative, evidence-based medicine.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.