Effect of compound fish oil capsules on microvascular function in hypertensive individuals: a triple-blind, randomized, placebo-controlled pilot trial
Liu B, Wang W, Teng A, Yu C, Liang Y, Liu A, Wu X, Li D, Ma H, Li K
Food & function · 0 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-01-01 · Food Funct · vol. 17 · número 8 · págs. 3611–3624
- Editorial
- Royal Society of Chemistry
- Citado
- 0 citas · más que el 13% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 73 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- microvascular function, hypertension, reactive hyperemia, endothelial-dependent vasodilation, left anterior descending artery, omega-3 fatty acids
- MeSH
- microcirculation, humans, hypertension, fish oils, capsules, pilot projects, blood pressure, aged, middle aged, female, male
10 autores
- Bingzheng Liu🇨🇳Qingdao University
- Wenlong Wang🇨🇳Shandong First Medical University
- Aiping Teng
- Chengcheng Yu
- Yaqian Liang
- Anchao Liu🇨🇳Qilu Institute of Technology
- Xiao Wu🇨🇳Qingdao University
- Duo Li🇨🇳Qingdao University
- Hui Ma
- Kelei Li🇨🇳Qingdao University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background. Research indicates that omega-3 fatty acids, resveratrol, astaxanthin, and coenzyme Q10 (CoQ10) possess anti-inflammatory properties, and their vascular benefits have been well-documented. This is a pilot study aimed at comprehensively evaluating the potential impact of the compound fish oil capsules on the microcirculation of multiple organs. Methods. In a triple-blind, randomized, placebo-controlled trial, 64 hypertensive patients were randomly assigned to either the compound fish oil (FO) group or the corn oil (CO) group (n = 32 per group) for a 3-week intervention. Participants were required to consume 2 capsules of the corresponding oil daily. The microcirculation functions of the heart, skin, and brain were examined by transthoracic Doppler echocardiography (TTDE), laser Doppler flowmetry (LDF), and magnetic resonance imaging (MRI), respectively. Data were primarily analyzed according to an intention-to-treat approach. Findings. In the left anterior descending artery (LAD), the end-diastolic velocity (EDV) and peak diastolic velocity (PDV) significantly increased in the FO group. The mean differences in change were 1.95 (0.13, 3.77; p = 0.036) and 2.95 (0.48, 5.41; p = 0.020), respectively. The resistance index (RI) showed a decreasing trend in the FO group, but the result was non-significant (p = 0.071). No significant differences were observed in blood pressure, brain and skin microcirculation parameters among the different groups. Interpretation. Compound fish oil capsules did not significantly improve RH. But compound fish oil capsules improved EDV and PDV levels in the LAD of hypertensive patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.