Magnesium supplementation as an adjunct to fluoxetine therapy for depression
Walyddaini AS, Lisal ST, Ilhamuddin, Zainuddin AA, Tanra AJ, Widianingsih Y, Syamsuddin S
East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-03-31 · East Asian Arch Psychiatry · vol. 36 · número 1 · pág. 19
- Editorial
- Hong Kong Academy of Medicine
- Citado
- 0 citas · más que el 26% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY-NC-ND
- Áreas de investigación
- Treatment of Major Depression · Magnesium in Health and Disease · Mental Health Treatment and Access
- Palabras clave
- magnesium supplementation, fluoxetine, depression, adjunctive therapy, serum serotonin, depressive symptoms, Hamilton Depression Rating Scale, young adults
- MeSH
- humans, magnesium, serotonin, fluoxetine, treatment outcome, drug therapy, combination, depression, dietary supplements, adolescent, adult, middle aged, female, male, young adult
7 autores
- Andi Soraya Walyddaini🇮🇩Hasanuddin University
- Sonny Teddy Lisal🇮🇩Hasanuddin University
- Ilhamuddin🇮🇩Hasanuddin University
- A A Z Andi Alfian Zainuddin🇮🇩Hasanuddin University
- Andi Jayalangkara Tanra🇮🇩Hasanuddin University
- Yuyun Widianingsih🇮🇩Hasanuddin University
- Saidah Syamsuddin🇮🇩Hasanuddin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To evaluate the effectiveness of magnesium supplementation as an adjunct to fluoxetine therapy for improving depressive symptoms and serum serotonin levels in patients with depression.
Methods
Consecutive patients aged 18 to 45 years who had been prescribed fluoxetine therapy for new-onset or chronic depression were recruited between November 2024 and February 2025 at the outpatient psychiatry clinic of Wahidin Sudirohusodo General Hospital and three affiliated hospitals in Makassar, Indonesia. Participants were randomised in an alternating sequence to receive either fluoxetine 20 mg/day alone or in combination with oral magnesium supplementation 250 mg/day. Outcomes were assessed at baseline and week 6. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Blood samples were collected to measure serum serotonin levels.
Results
In total, 32 women and 8 men who received either fluoxetine alone (n = 20) or in combination with magnesium (n = 20) were included in the analysis. Both groups showed significant reductions in HDRS total score from baseline to week 6 (p 2 = 0.528, p < 0.001) after adjustment for baseline HDRS score and demographic covariates, indicating a large effect size.
Conclusion
Magnesium supplementation as an adjunct to fluoxetine therapy improves HDRS total score in patients with depression.
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