The effects of caffeine on short-latency afferent inhibition measured with paired-pulse conventional and threshold-tracking TMS
Carrozzo C, Cannazza M, Fratini D, Fanella G, Cengiz B, Di Lazzaro V, Samusyte G, Tankisi H
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 1 cita
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Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Organización sin fines de lucro
- Dagmar Marshalls Fond
- Organización sin fines de lucro
- Aase og Ejnar Danielsens Fond
- Organización sin fines de lucro
- Lundbeckfonden
- Organización sin fines de lucro
- Grosserer L. F. Foghts Fond
- Organización sin fines de lucro
- Aage og Johanne Louis-Hansens Fond
- Empresa
- Lundbeck Foundation
- Empresa
- Wholesaler L F Foght Fund
- Subvenciones
- Lundbeckfonden (R290\u20132018\u2013751); Lundbeckfonden (R346‐2020‐1946)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2026-03-22 · Clin Neurophysiol · vol. 187 · pág. 2111857
- Editorial
- Elsevier BV
- Citado
- 2 citas · más que el 94% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Transcranial Magnetic Stimulation Studies · Coffee research and impacts · Neuroscience and Neuropharmacology Research
- Palabras clave
- caffeine, short-latency afferent inhibition, cortical excitability, sensorimotor integration, paired-pulse TMS, cholinergic system, interstimulus interval, placebo-controlled crossover trial
- MeSH
- motor cortex, afferent pathways, humans, caffeine, central nervous system stimulants, cross-over studies, double-blind method, reaction time, evoked potentials, motor, neural inhibition, adult, female, male, transcranial magnetic stimulation, young adult
8 autores
- Camilla Carrozzo🇮🇹🇩🇰Università Campus Bio-Medico; Aarhus University Hospital
- Martina Cannazza🇮🇹🇩🇰Università Campus Bio-Medico; Aarhus University Hospital
- Diletta Fratini🇮🇹🇩🇰Università Campus Bio-Medico; Aarhus University Hospital
- Gaia Fanella🇩🇰Aarhus University; Aarhus University Hospital
- Bülent Çengiz🇹🇷Gazi University
- Vincenzo Di Lazzaro🇮🇹Università Campus Bio-Medico; Campus Bio Medico University Hospital
- Gintautė Samušytė🇱🇹Lithuanian University of Health Sciences; Hospital of Lithuanian University of Health Sciences Kaunas Clinics
- Hatice Tankişi🇩🇰 · autor de correspondenciaAarhus University; Aarhus University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Transcranial Magnetic Stimulation (TMS) tests of Short-latency Afferent Inhibition (SAI) by conventional amplitude (A-SAI) and threshold-tracking (T-SAI) are important methods to investigate cortical excitability and, more specifically, sensory motor-integration. Since beverages containing caffeine are widely consumed, and caffeine has been reported to affect cortical excitability, it is of interest to explore if SAI is modulated by caffeine.
Methods
Twenty healthy subjects (11 females, 9 males; mean age: 27.0 ± 5.53) were studied in a single fixed-dose randomized double-blind placebo-controlled cross-over trial of 200 mg caffeine or placebo administered as chewing gum. Changes in A-SAI and T-SAI at 12 interstimulus intervals between 18 ms and 30 ms were assessed by conventional fixed stimulus and threshold-tracking techniques.
Results
There was no effect of caffeine on SAI across the full range of ISIs with either of the methods. However, caffeine significantly enhanced peak A-SAI (ISIs 19-21 ms) when compared to placebo (p = 0.011), while no effect on peak T-SAI was found.
Conclusion
Caffeine enhances SAI as evaluated with the conventional A-SAI protocol, but not with the threshold-tracking method.
Significance
Caffeinés effect may result from its modulation of the cholinergic system, providing insights into both its physiological action and brain disorder pathophysiology.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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