Secondary analysis of omega-3 supplementation: Alteration of lipid mediators and inflammation in older adults engaged in a home-based and vibration exercise program
Li DCW, Haß U, Herpich C, Rudloff S, Norman K
Nutrition research (New York, N.Y.) · 0 citas
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- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-03-07 · Nutr Res · vol. 149 · págs. 139–147
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 12% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Exercise and Physiological Responses · Inflammatory mediators and NSAID effects
- Palabras clave
- omega-3 supplementation, lipid mediators, inflammation, older adults, vibration training, home-based exercise, prostaglandin E2, leukotriene B4, resolvin E1, docosahexaenoic acid, eicosapentaenoic acid, algae oil, IL-10, interleukin-1 receptor antagonist, insulin-like growth factor I, C-reactive protein
- MeSH
- humans, inflammation, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, leukotriene b4, dinoprostone, inflammation mediators, exercise, dietary supplements, aged, middle aged, female, male, biomarkers, specialized pro-resolving mediators
5 autores
- Donna C.W. Li🇩🇪German Institute of Human Nutrition
- Ulrike Haß🇩🇪University of Potsdam
- Catrin Herpich🇩🇪German Institute of Human Nutrition
- Stefan Rudloff🇩🇪Humboldt-Universität zu Berlin; Charité - Universitätsmedizin Berlin
- Kristina Norman🇩🇪 · autor de correspondenciaUniversity of Potsdam; Humboldt-Universität zu Berlin; German Centre for Cardiovascular Research; German Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Omega-3 fatty acid supplementation may influence lipid mediators that regulate inflammation, but its effects in older adults are not well defined. This secondary analysis examined the effects of omega-3 supplementation on lipid mediators and inflammatory markers in older adults performing a home-based and vibration exercise program. We hypothesized that omega-3 supplementation would reduce circulating prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) and increase resolvin E1 (RvE1). Forty participants (mean age 69 years, 50% women) were randomly assigned to receive an algae-oil omega-3 supplementation (1397 mg docosahexaenoic acid, 749 mg eicosapentaenoic acid) or no supplementation for 8 weeks. Plasma PGE2, LTB4, RvE1, and inflammatory markers were measured before and after the intervention. Directional changes were classified as increase, no change, or decrease, and correlations between lipid mediator and inflammatory marker responses were analyzed. PGE2 decreased more in the omega-3 group than in controls (time × group P = .043), whereas LTB4 (time P < .001) and RvE1 (time P = .003) declined similarly in both groups. Supplementation was associated with greater reductions in interleukin 10 and interleukin 1 receptor antagonist, and a larger increase in insulin-like growth factor 1. Changes in PGE2 correlated with C reactive protein (ρ = -0.412, P = .008) and like growth factor 1 (ρ = 0.345, P = .029). Omega-3 supplementation selectively lowered PGE2 independent of exercise effects, while exercise contributed to decreases in LTB4 and RvE1. These findings indicate that omega-3 supplementation modifies lipid mediators linked to inflammation in older adults.
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