Do the Effects of Early Time-Restricted Eating Vary by Cardiometabolic Phenotype, Age, Sex, or Race? A Secondary Analysis of a Randomized Controlled Trial
Rehman Z, Altonji OM, Steger FL, Jamshed H, Richman JS, Warriner AH, Peterson CM
The Journal of nutrition · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Nutrition Obesity Research Center, University of Washington
- Gobierno
- National Institutes of Health
- Universidad u hospital
- Diabetes Research Center
- Universidad u hospital
- Nutrition Obesity Research Center, University of Alabama at Birmingham
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIDDK NIH HHS
- Universidad u hospital
- The University of Alabama at Birmingham Nutrition Obesity Research Center
- Gobierno
- NCATS NIH HHS
- Subvenciones
- Diabetes Research Center (P30DK079626)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2026-04-05 · J Nutr · vol. 156 · número 6 · pág. 101526
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 91% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Diet and metabolism studies
- Palabras clave
- time-restricted eating, intermittent fasting, hypertension, prediabetes, insulin resistance, hypercholesterolemia, morbid obesity, blood pressure, glycemic control, HbA1c, LDL cholesterol, racial differences, sex differences, age differences, cardiometabolic risk factors, weight loss
- MeSH
- humans, hypertension, prediabetic state, insulin resistance, obesity, weight loss, fasting, age factors, sex factors, blood pressure, phenotype, adult, aged, middle aged, female, male, intermittent fasting
7 autores
- Zaurayze Rehman🇺🇸University of Alabama; University of Alabama at Birmingham; UAB Medicine
- Olivia M. Altonji🇺🇸University of Alabama at Birmingham
- Felicia L. Steger🇺🇸University of Alabama at Birmingham; University of Kansas Medical Center; UAB Medicine
- Humaira Jamshed🇺🇸🇵🇰University of Alabama at Birmingham; Habib University
- Joshua Richman🇺🇸University of Alabama at Birmingham
- Amy H. Warriner🇺🇸University of Alabama at Birmingham
- Courtney M. Peterson🇺🇸 · autor de correspondenciaHarvard University; University of Alabama at Birmingham
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Time-restricted eating (TRE), the most popular form of intermittent fasting, induces weight loss and may improve cardiometabolic health, but less is known about the effects in certain populations.
Objectives
We performed a secondary analysis to determine the effectiveness of early TRE (eTRE) in subgroups with elevated cardiometabolic risk factors and to determine whether the effects vary by age, sex, or race.
Methods
Adults aged 25-75 y with obesity (BMI: 30-60 kg/m2) undergoing weight-loss treatment were randomized to eat in an 8-h period from 07:00 to 15:00 (eTRE) or over a ≥12-h period (control) for 14 wk. We performed subgroup analyses to: 1) assess the effects of eTRE in individuals with hypertension, prediabetes, insulin resistance, hypercholesterolemia, and severe obesity, and 2) determine whether the effects differ by age, sex, or race.
Results
eTRE lowered diastolic blood pressure by 9 ± 4 mm Hg (P = 0.047) in adults with systolic blood pressure ≥130 mm Hg and by 4 ± 2 mm Hg (P = 0.04) in adults with hypertension relative to the control group. In prediabetic adults, eTRE lowered hemoglobin A1c by 0.3% ± 0.1% (P = 0.04), whereas in adults with hypercholesterolemia, it reduced HOMA-IR by 2.96 ± 1.46 (P = 0.04). Interestingly, in adults with severe obesity, eTRE increased total and low-density lipoprotein cholesterol by 21 ± 9 and 17 ± 7 mg/dL, respectively (P = 0.03). There were no differences by sex or age. eTRE improved blood pressure and glycemic endpoints more in Black participants than White participants, although the number of Black participants was small (n = 13).
Conclusions
The results of this exploratory analysis suggest eTRE may be a promising intervention to treat hypertension and prediabetes. Any differences by sex and age are likely minor. eTRE's effects on cholesterol in adults with severe obesity and potential racial differences merit further investigation. This trial was registered at clinicaltrials.gov as NCT03459703.
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