Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial
Fernandez-Garrido J, Martin EG, Saez-Berlanga A, Gargallo-Bayo P, Gene-Morales J, Alix-Fages C, Jiménez-Martínez P, Caballero O, Salvador-Palmer R, Colado JC
Experimental gerontology · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Generalitat Valenciana
- Gobierno
- Conselleria d'Educació, Investigació, Cultura i Esport
- Gobierno
- European Social Fund
- Gobierno
- Generalitat of Valencia Ministry of Education Culture Universities and Employment
- Gobierno
- European Social Fund Plus
- Subvenciones
- Conselleria d'Educació, Investigació, Cultura i Esport (CIACIF/2021/189)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2026-04-04 · Exp Gerontol · vol. 218 · pág. 113122
- Editorial
- Elsevier BV
- Citado
- 4 citas · más que el 99% de estudios similares · 12.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 118 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Exercise and Physiological Responses
- Palabras clave
- high-load resistance training, creatine supplementation, older adults, neuroplasticity, brain-derived neurotrophic factor, oxidative stress, inflammation, aquatic exercise, resistance bands, physical function, cognitive performance, quality of life, isokinetic strength, upper limb strength, F2-isoprostanes, glutathione peroxidase, interleukin-6
- MeSH
- humans, inflammation, creatine, double-blind method, cognition, oxidative stress, neuronal plasticity, quality of life, dietary supplements, aged, middle aged, female, male, muscle strength, resistance training, physical functional performance
10 autores
- Julio Fernández-Garrido🇪🇸Universitat de València
- Ezequiel Martin🇪🇸Universitat de València
- Ángel Saez-Berlanga🇪🇸Universitat de València
- Pedro Gargallo🇪🇸 · autor de correspondenciaUniversitat de València
- Javier Gené‐Morales🇪🇸Universitat de València
- Carlos Alix‐Fages🇪🇸Universitat de València
- Pablo Jiménez‐Martínez🇪🇸Universitat de València
- Oscar Caballero🇪🇸Universitat de València
- Rosario Salvador Palmer🇪🇸Universitat de València
- Juan C. Colado🇪🇸Universitat de València
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To compare two 16-week high-load, velocity-intentional resistance training programs-elastic bands (HL-VIRT-EB) vs. water-based (HL-VIRT-AQ)-combined with creatine or placebo supplementation on neuroplasticity, oxidative stress, inflammation, strength, physical function, cognition, and quality of life in older adults.
Methods
In a randomized controlled trial, 103 community-dwelling older adults (57 women, 46 men; 68.2 ± 4.6 y) were assigned to HL-VIRT-EB + Creatine, HL-VIRT-EB + Placebo, HL-VIRT-AQ + Creatine, HL-VIRT-AQ + Placebo, Control+Creatine, or Control+Placebo. Training was performed 3×/week (60 min). Creatine was consumed daily (3 g). Outcomes included brain-derived neurotrophic factor, F2-isoprostanes (F2-iso), glutathione peroxidase (GPx), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), isokinetic strength (knee/elbow, 60°·s-1), handgrip, timed up-and-go, 30-s chair-stand, 6-min walk, trail-making test, and SF-36. ANCOVAs and correlations were conducted.
Results
Both training modalities produced significant improvements in neurocognitive biomarkers, oxidative/inflammatory profiles, strength, functional performance and quality of life (p < 0.05). HL-VIRT-AQ yielded greater reductions in F2-iso and TNF-α and larger gains in functional tests compared to HL-VIRT-EB (d = 0.12-1.18), which elicited superior upper-limb strength gains. Creatine provided additional benefits, increasing GPx, reducing IL-6/TNF-α and improving strength and function when combined with exercise modalities. Creatine alone reduced F2-iso and TNF-α and improved perceived health versus placebo.
Conclusions
High-load, velocity-intentional resistance training-on land or in water-effectively improves neurocognition, oxidative balance, inflammation, strength, function, and quality of life in older adults. Aquatic training is particularly effective for attenuating oxidative stress and inflammation. Creatine supplementation confers complementary, modality-specific benefits and supports their use in combination to high-speed resistance exercise to promote healthy aging.
Clinical trial registration id
NCT06620666 (ClinicalTrials.gov).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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