Effects of vitamin D<sub><b>3</b></sub> supplementation on cardiac, muscle, and immune responses after a marathon race: a single-blind, placebo-controlled trial
Weng PW, Nanda JD, Chien YH, Lin CF, Cheng SC, Yang MT
Journal of the International Society of Sports Nutrition · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Science and Technology Council
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-04-12 · J Int Soc Sports Nutr · vol. 23 · número 1 · pág. 2657316
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 20% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Vitamin D Research Studies · Sports Performance and Training
- Palabras clave
- vitamin D3 supplementation, marathon running, endurance exercise, exercise-induced muscle damage, oxidative stress, protein carbonyls, creatine kinase, creatine kinase-MB, cardiac stress, immune response, lymphocyte subsets, neutrophils, post-exercise recovery, antioxidant enzymes
- MeSH
- muscle, skeletal, heart, humans, thiobarbituric acid reactive substances, cholecalciferol, single-blind method, oxidative stress, dietary supplements, adult, middle aged, female, male, protein carbonylation, biomarkers, marathon running, post-exercise recovery
6 autores
- Pei‐Wei Weng🇹🇼Taipei Medical University
- Josephine Diony Nanda🇮🇩🇹🇼Universitas Gadjah Mada; Taipei Medical University
- Yu-Hsiu Chien🇹🇼National Taiwan Sport University
- Chiou‐Feng Lin🇹🇼Taipei Medical University
- Shih-Chung Cheng🇹🇼National Taiwan Sport University
- Ming‐Ta Yang🇹🇼 · autor de correspondenciaTaipei Medical University Hospital; Taipei Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Strenuous endurance exercise imposes substantial physiological stress on the cardiovascular system and has been associated with transient elevations in cardiac biomarkers. Vitamin D₃ has been suggested to influence oxidative stress and immune responses. In this study, we investigated the effects of vitamin D₃ supplementation on biomarkers of cardiac, muscle, and immune responses following a marathon race.
Methods
Twenty-one amateur runners were allocated to either a vitamin D₃ supplementation group (receiving vitamin D₃ for 8 weeks) or a placebo group. All participants completed an official full marathon (42.195 km). Blood biomarkers were measured from 24 h before to 24 h after the race.
Results
Post-race increases in markers of muscle damage and cardiac stress were observed. Vitamin D₃ supplementation was associated with attenuated elevations in selected biomarkers demonstrating significant interaction effects. Compared with the placebo group, the vitamin D₃ group demonstrated attenuation of protein carbonyls (PC), the only oxidative stress marker showing a significant Group × Time interaction. No significant interaction effects were observed for thiobarbituric acid reactive substances (TBARS) or antioxidant enzymes. Both groups showed post-race increases in white blood cell counts, particularly neutrophils, whereas lymphocyte counts significantly decreased at 0.5 h and 2 h post-race. Immunoprofiling revealed time-dependent alterations in selected immune cell subsets, although no significant interaction effects were detected. Descriptive differences in recovery patterns were observed between groups, and exploratory correlation analyses suggested time-specific associations between immune cell subsets and biochemical markers during recovery.
Conclusion
Vitamin D₃ supplementation may attenuate PC responses and was associated with lower creatine kinase (CK) and creatine kinase-MB (CK-MB) levels at 24 h post-race following marathon running. Immune alterations were time-dependent, with descriptive differences in recovery patterns between groups.
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