Impact of vitamin D status and supplementation on exploratory inflammatory biomarkers in preschoolers with asthma
El Abd A, Trottier H, Tse SM, Mâsse B, Mailhot G, Alos N, Chen BA, Jensen ME, Radhakrishnan D, Yang CL, Ducharme FM
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Centre hospitalier universitaire Sainte-Justine
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- Fonds de Recherche du Québec - Santé
- Gobierno
- FRQS
- Universidad u hospital
- CHUSJ
- Subvenciones
- Canadian Institutes of Health Research (153252); Fonds de Recherche du Québec - Santé (333208); Canadian Institutes of Health Research (K1A 0W9)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2026-04-10 · Ann Allergy Asthma Immunol · vol. 137 · número 1 · págs. 53–63.e4
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 23% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Vitamin D Research Studies · Asthma and respiratory diseases · Antioxidant Activity and Oxidative Stress
- Palabras clave
- vitamin D supplementation, 25-hydroxyvitamin D, vitamin D status, preschool children, childhood asthma, C-reactive protein, inflammatory markers, neutrophils, neutrophilic inflammation
- MeSH
- neutrophils, humans, asthma, inflammation, cholecalciferol, vitamin d, c-reactive protein, dietary supplements, child, preschool, infant, female, male, biomarkers
11 autores
- Asmae El Abd🇨🇦 · autor de correspondenciaCHU Sainte-Justine Research Center; Université de Montréal
- Helen Trottier🇨🇦Centre Hospitalier Universitaire Sainte-Justine; CHU Sainte-Justine Research Center; Université de Montréal
- Sze Man Tse🇨🇦Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal
- Benoît R. Mâsse🇨🇦Centre Hospitalier Universitaire Sainte-Justine; CHU Sainte-Justine Research Center; Université de Montréal
- Geneviève Mailhot🇨🇦Centre Hospitalier Universitaire Sainte-Justine; CHU Sainte-Justine Research Center; Université de Montréal
- Nathalie Alos🇨🇦Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal
- Breanna A. Chen🇨🇦Western University
- Megan E. Jensen🇦🇺Hunter Medical Research Institute; University of Newcastle Australia
- Dhenuka Radhakrishnan🇨🇦University of Ottawa; Children's Hospital of Eastern Ontario
- Connie L Yang🇨🇦BC Children's Hospital
- Francine Monique Ducharme🇨🇦Centre Hospitalier Universitaire Sainte-Justine; CHU Sainte-Justine Research Center; Université de Montréal
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D supplementation may improve asthma by modulating inflammation, but its effects in preschoolers with virus-induced asthma remain underexplored.
Objective
To measure the association between serum 25-hydroxyvitamin D (25(OH)D) and inflammatory biomarkers and the impact of vitamin D supplementation on these biomarkers.
Methods
We conducted a nested study within a 7-month randomized placebo-controlled trial. Children aged 1 to 5 years with virus-induced asthma received vitamin D3 in 2 oral boluses (100,000 IU) 3.5 months apart, with a daily (400 IU) supplement, or placebo boluses and daily supplement. Serum 25(OH)D and C-reactive protein (CRP) were measured at baseline, 3.5 months, and 7 months, whereas blood cells were measured at baseline and 7 months. Primary outcomes were CRP across time points and change from baseline in CRP at 3.5 and 7 months, analyzed using generalized estimating equation and mixed-effects models.
Results
Among 236 (118 Vitamin D: 118 placebo) children (64.4% male), no significant association was observed between CRP and 25(OH)D. However, neutrophils were inversely associated with 25(OH)D (adjusted β [95% CI]= -0.016 (-0.027 to -0.005) × 10⁹ cells/L, n = 198). Compared with placebo, vitamin D supplementation led to a greater reduction from baseline in CRP over time (adjusted β [95% CI] = -3.154 [-5.978 to -0.330] mg/L, n = 174), and neutrophils at 7 months (adjusted β [95% CI] = -0.657 [-1.288 to -0.026] × 10⁹ cells/L, n = 110). No associations were observed with other blood cell biomarkers.
Conclusion
In preschoolers with virus-induced asthma, serum 25(OH)D was inversely associated with neutrophils, and vitamin D supplementation significantly reduced CRP and neutrophils over time, suggesting modulation of neutrophilic inflammation.
Trial registration
ClinicalTrials.gov Identifier: NCT03365687.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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