Safety analysis of repeated low-level red light therapy on cone mosaic and microvasculature by adaptive optics scanning laser ophthalmoscopy
Yue Y, Zhang N, Liu KY, Zhong YY, Wang H, Liu SL, Wan WJ, Zhang YL, Deng WL
Photodiagnosis and photodynamic therapy · 0 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Chongqing Municipal Education Commission
- Subvenciones
- National Natural Science Foundation of China (81900845); National Natural Science Foundation of China (81371043); National Natural Science Foundation of China (82201168); National Natural Science Foundation of China (82571201); National Natural Science Foundation of China (81970832); Chongqing Municipal Education Commission (KJZD-K202400402)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2026-04-11 · Photodiagnosis Photodyn Ther · vol. 59 · pág. 105473
- Editorial
- Elsevier BV
- Citado
- 2 citas · más que el 98% de estudios similares · 10.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinal Diseases and Treatments · Laser Applications in Dentistry and Medicine
- Palabras clave
- Scanning laser ophthalmoscopy, Retinal, Ophthalmoscopy, Foveal, Adaptive optics, Cone (formal languages), Retina
- MeSH
- retinal vessels, humans, myopia, ophthalmoscopy, cross-sectional studies, child, female, male, retinal cone photoreceptor cells, microvessels, low-level light therapy, red light
9 autores
- Yu Yue🇨🇳The Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Ni Zhang🇨🇳The Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Ke-Yu Liu🇨🇳The Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Yuanyuan Zhong🇨🇳The Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Han Wang🇨🇳The Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Shu-Lin Liu🇨🇳The Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Wen-Juan Wan🇨🇳The Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Yan-lai Zhang🇨🇳 · autor de correspondenciaThe Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Wen-Li Deng🇨🇳 · autor de correspondenciaThe Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Despite the growing use of repeated low-level red light (RLRL) therapy for myopic children, its safety remains controversial. This study aimed to analyze macular cone morphology and retinal microvascular hemodynamics using adaptive optics scanning laser ophthalmoscopy (AOSLO) to evaluate retinal microstructural impacts.
Design
Cross-sectional study.
Methods
Three groups were recruited: Myopia-RLRL (20 eyes; ≥8 months treatment), Myopia-Untreated (32 eyes), and Non-Myopic (14 eyes). RLRL therapy was administered using a 650 nm laser at 0.29 mW, twice daily for 3 min per session. AOSLO was used to assess cone morphology (density, spacing, regularity, dispersion) and retinal microvasculature parameters (vessel diameter, lumen diameter, blood flow velocity).
Results
Cone density was higher in the Non-Myopic group (45,649 ± 5092/mm²) compared to the Myopia-Untreated group (40,202 ± 7365/mm², P = 0.013), with no significant difference versus the Myopia-RLRL group (41,274 ± 6228/mm², P = 0.627). Cone spacing was enlarged in myopic groups relative to non-myopic (P < 0.05). Cone dispersion was lower in the Myopia-RLRL group (16.47 ± 2.43%) than in the Myopia-Untreated (17.36 ± 2.14%, P = 0.030) and Non-Myopic (17.80 ± 2.25%, P = 0.024) groups. No significant intergroup differences were found in cone regularity or microvasculature. Cone density positively correlated with spherical equivalent refraction (r = 0.541) and negatively with axial length (r=-0.594; both P < 0.001).
Conclusions
After 8 months of RLRL therapy, there was no significant loss of cone density or issues with retinal microvasculature. Assessment of retinal arteriole and venule diameters and flow velocity also showed no significant differences. The reduced cone dispersion in the RLRL group suggests potential photobiomodulation effects on photoreceptor organization, indicating the therapy's safety and potential benefits.
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