Intermittent fasting and cardiometabolic responses under cardiac stress: a systematic review of preclinical studies
Almeida Sousa G, Moreira Reis Filho J, Batista H, Sernizon Guimarães N, Joviano-Santos JV
Life sciences · 0 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Organización sin fines de lucro
- Fundação Educacional Lucas Machado
- Gobierno
- National Council for Scientific and Technological Development
- Organización sin fines de lucro
- Lucas Machado Educational Foundation
- Gobierno
- CAPES
- Gobierno
- Minas Gerais State Foundation of Support to the Research
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais (APQ-03584-25)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2026-04-13 · Life Sci · vol. 395 · pág. 124393
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 16% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Cardiac Ischemia and Reperfusion · Cardiac Fibrosis and Remodeling
- Palabras clave
- intermittent fasting, cardiac stress, cardioprotection, cardiometabolic health, myocardial infarction, ischemia-reperfusion injury, doxorubicin cardiotoxicity, pulmonary arterial hypertension, atherosclerosis, cardiac hypertrophy, myocardial fibrosis, NF-κB, SIRT3, AMPK, mitochondrial function, lipid metabolism, fasting duration
- MeSH
- animals, humans, mice, cardiovascular diseases, fasting, stress, physiological, intermittent fasting
5 autores
- Gabriel Almeida Sousa🇧🇷Faculdade de Ciências Médicas de Minas Gerais
- Juliano Moreira Reis Filho🇧🇷Faculdade de Ciências Médicas de Minas Gerais
- Humberto Batista🇧🇷Faculdade de Ciências Médicas de Minas Gerais
- Nathalia Sernizon Guimarães🇧🇷Universidade Federal de Minas Gerais
- Julliane Vasconcelos Joviano‐Santos🇧🇷 · autor de correspondenciaFaculdade de Ciências Médicas de Minas Gerais
Resumen
El texto original del estudio, en el idioma en que se publicó.
Intermittent fasting (IF) has emerged as a dietary strategy with benefits that extend beyond weight management and glycemic control. Although growing evidence supports its favorable effects on cardiometabolic health, the impact of IF under conditions of cardiac stress remains poorly characterized. Since clinical trials cannot ethically expose patients to acute cardiac stress during IF protocols, preclinical models are essential to elucidate its potential cardioprotective mechanisms. This systematic review aimed to synthesize the preclinical evidence on the effects of IF in models of cardiac stress. Following a registered protocol (PROSPERO:#CRD42023466215), we searched databases for preclinical studies evaluating IF under cardiac stress. Models included atherosclerosis induction, diet modulation, hypercholesterolemic mice, doxorubicin-induced cardiotoxicity, pulmonary arterial hypertension, myocardial infarction, ischemia-reperfusion injury, among others. All IF regimens, encompassing variations in timing, frequency, and type, were considered. Clinical trials, observational studies, reviews, meta-analyses, updates, guidelines were excluded. Thirty-two studies involving 451 predominantly male animals were included. Approximately 80% reported that IF improved cardiovascular outcomes, reducing blood pressure, cardiac hypertrophy, fibrosis, and ischemic injury while enhancing vascular and metabolic function. Mechanistically, IF protects the heart under stress by downregulating NF-κB, IL-1β, and TNF, and activating SIRT3 and AMPK pathways, improving mitochondrial function, lipid metabolism, and cardiac energy homeostasis. Cardioprotective benefits were dependent on fasting duration and regimen, emphasizing the importance of metabolic context. In conclusion, IF appears to enhance cardiovascular resilience under stress through multiple metabolic and molecular pathways. These findings support further clinical investigation of IF as a potential adjunct strategy for cardiometabolic protection under stress.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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