Cyanoacrylate Adhesive With Low-Level Laser Therapy for Sutureless Periodontal Flap Closure: A Pilot Randomized Controlled Trial
Sharma K, Mehrotra S
Lasers in surgery and medicine · 0 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-04-15 · Lasers Surg Med · vol. 58 · número 5 · págs. 418–428
- Editorial
- Wiley
- Citado
- 1 cita · más que el 94% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- De pago
- Áreas de investigación
- Surgical Sutures and Adhesives · Laser Applications in Dentistry and Medicine · Periodontal Regeneration and Treatments
- Palabras clave
- cyanoacrylate adhesive, low-level laser therapy, periodontal flap surgery, periodontitis, postoperative pain, analgesic use, wound healing, clinical attachment level, probing depth, patient treatment preferences, silk suture, adjunctive therapy, patient satisfaction, treatment feasibility, cost-effectiveness
- MeSH
- surgical flaps, humans, cyanoacrylates, tissue adhesives, treatment outcome, suture techniques, prospective studies, feasibility studies, pilot projects, wound healing, adult, female, male, young adult, low-level light therapy, sutureless surgical procedures, postoperative pain
2 autores
- Kratee Sharma🇮🇳 · autor de correspondenciaTeerthanker Mahaveer University; Mahaveer University
- Shalabh Mehrotra🇮🇳Teerthanker Mahaveer University; Mahaveer University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Conventional suturing in periodontal flap surgery may increase postoperative discomfort and requires additional visits for suture removal. Cyanoacrylate tissue adhesives and low-level laser therapy (LLLT) have individually shown benefits in wound healing and postoperative symptom reduction. This pilot randomized controlled trial evaluated the feasibility and preliminary clinical outcomes of a sutureless periodontal flap closure technique using cyanoacrylate adhesive with adjunctive LLLT compared with conventional suturing.
Methods
This prospective, parallel-group pilot randomized controlled trial was conducted over a 4-month period from October 2025 to January 2026, in the Department of Periodontics, Kothiwal Dental College and Research Centre, Moradabad, India. 20 systemically healthy adults (mean age 31.9 ± 3.6 years; 55% males) with Stage II or III, Grade B periodontitis requiring flap surgery were randomly allocated (1:1) to conventional silk sutures (control, n = 10) or cyanoacrylate adhesive with LLLT (intervention, n = 10). The primary outcome was postoperative pain measured using a 100-mm visual analog scale. Secondary outcomes included wound healing index, analgesic consumption, plaque index, probing pocket depth (PPD), clinical attachment level (CAL), and patient treatment preference. Statistical analysis was performed using mixed-effects models and generalized linear mixed models, with independent t-test or Mann-Whitney U test for between-group comparisons. Statistical significance was set at p < 0.05, and 95% confidence intervals were calculated.
Results
All participants completed the study with 100% follow-up and no adverse events. Baseline demographic characteristics were comparable between groups (p > 0.05). The intervention group demonstrated significantly lower analgesic consumption (mean difference 2.30 tablets; 95% confidence interval 1.18-3.42; p = 0.001) and higher patient preference scores (mean difference 1.50 points; 95% confidence interval 0.83-2.17; p = 0.001). Postoperative pain scores were consistently lower and early wound healing scores were higher in the intervention group across follow-up visits (p 0.05).
Conclusion
Cyanoacrylate adhesive with adjunctive low-level laser therapy appears feasible and may improve early postoperative outcomes following periodontal flap surgery. Larger randomized trials are required to confirm these findings.
Trial registration
The study was prospectively registered with the Clinical Trials Registry-India (CTRI/2025/09/095379) on September 24, 2025.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.