Combined effectiveness of omega-3 PUFA-rich fish oil supplementation and high-intensity interval training in obesity associated metabolic dysfunction: Protocol for a double-blind, randomized clinical trial
Azari H, Combs D, Galindo S, Jafarabadi GS, Chemitiganti R, Park OH, Moustaid-Moussa N, Dhanasekara CS, Albracht-Schulte K
Contemporary clinical trials · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Texas Tech University
- Gobierno
- National Institute of Food and Agriculture
- Subvenciones
- National Institute of Food and Agriculture (2020-67034-31761)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2026-04-15 · Contemp Clin Trials · vol. 165 · pág. 108311
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 21% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Gut microbiota and health · Exercise and Physiological Responses
- Palabras clave
- omega-3 polyunsaturated fatty acids, fish oil supplementation, high-intensity interval training, obesity, metabolic dysfunction, low-grade inflammation, gut dysbiosis, overweight, exercise intensity, dietary supplementation
- MeSH
- humans, obesity, inflammation, fatty acids, omega-3, fish oils, body mass index, double-blind method, dietary supplements, adult, middle aged, female, male, dysbiosis, gastrointestinal microbiome, high-intensity interval training
9 autores
- Hushyar Azari🇺🇸Texas Tech University
- Diana Combs🇺🇸Texas Tech University
- Salvador de Lara Galindo🇺🇸Texas Tech University
- Golbarg Shabani Jafarabadi🇺🇸Texas Tech University
- Rama Chemitiganti🇺🇸Texas Tech University Health Sciences Center
- Oak‐Hee Park🇺🇸Texas Tech University
- Naïma Moustaïd‐Moussa🇺🇸Texas Tech University; Texas Tech University Health Sciences Center
- Chathurika Samudani Dhanasekara🇺🇸Texas Tech University Health Sciences Center
- Kembra Albracht‐Schulte🇺🇸 · autor de correspondenciaTexas Tech University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objective
Obesity rates continue to rise globally, highlighting the need for prevention and targeted treatment strategies. Chronic systemic low-grade inflammation and gut microbiota dysbiosis are key contributors to obesity-associated metabolic diseases. Anti-inflammatory dietary components, such as fish oil rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs), reduce inflammation and improve metabolic outcomes. Similarly, physical activity improves metabolic health and attenuates chronic systemic inflammation, with varying benefits according to exercise intensity. While both interventions independently modulate inflammation and gut microbiota, their combined effects warrant further research. This study investigates the combined impact of n-3 PUFA supplementation and high-intensity interval training (HIIT) on obesity-related inflammation and gut microbiota dysbiosis, hypothesizing that improvements in gut microbiota composition driven by n-3 PUFAs may enhance the metabolic benefits of exercise.
Design and methods
Adults with a body mass index (BMI) ≥ 25 kg/m2 are randomized to receive either 4 g/day n-3 PUFA or safflower oil (placebo) for 10 weeks. During weeks 0-4, participants take the assigned supplement. Beginning in week 4, one n-3 PUFA group and one placebo group will additionally complete 4-weeks of HIIT. Control groups perform low-intensity training (LIT) for 4 weeks. The last two weeks are a detraining phase with continued supplementation.
Discussion
This study explores the benefits of combining short-term HIIT and n-3 PUFA supplementation in individuals with overweight or obesity. The findings inform measurable, time-efficient interventions that target systemic inflammation, gut microbiota dysbiosis, and metabolic dysfunctions.
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