Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk
Cook KL, Giles ED, Sekela JJ, Simpson JB, Redinbo MR, Wilson AS, Umar S, Befort CA, Kimler BF, Hursting SD, Fabian CJ
Cancer prevention research (Philadelphia, Pa.) · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Morris Family Foundation
- Organización sin fines de lucro
- Breast Cancer Research Foundation
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- Congressionally Directed Medical Research Programs
- Gobierno
- NCI NIH HHS
- Gobierno
- National Institute of General Medical Sciences (NIGMS)
- Gobierno
- NIGMS NIH HHS
- Organización sin fines de lucro
- Morris Family Foundation (The Morris Family Foundation)
- Gobierno
- Congressionally Directed Medical Research Programs (CDMRP)
- Organización sin fines de lucro
- Breast Cancer Research Foundation (BCRF)
- Gobierno
- National Cancer Institute (NCI)
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute of General Medical Sciences (GM135218); National Cancer Institute (P30CA012197); Congressionally Directed Medical Research Programs (W81XWH-22-1-0055); Congressionally Directed Medical Research Programs (W81XWH-20-1-0014); National Cancer Institute (P30-CA-168524); National Institute of General Medical Sciences (GM137286)
Según 12 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-04-18 · Cancer Prev Res (Phila) · vol. 19 · número 8 · págs. 473–488
- Editorial
- American Association for Cancer Research
- Citado
- 1 cita · más que el 84% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 71 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Gut microbiota and health · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- omega-3 fatty acids, weight loss, gut microbiota, breast cancer risk, obesity, short-chain fatty acids, Firmicutes/Bacteroidetes ratio, propionate, butyrate, estradiol, adiponectin/leptin ratio, C-reactive protein, inflammation, postmenopausal women, eicosapentaenoic acid, docosahexaenoic acid, Phocaeicola vulgatus, Alistipes putredinis
- MeSH
- feces, humans, breast neoplasms, obesity, weight loss, fatty acids, omega-3, body mass index, risk factors, pilot projects, dietary supplements, aged, middle aged, female, microbiota, gastrointestinal microbiome
11 autores
- Katherine Loree Cook🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Erin Danielle Giles🇺🇸University of Michigan; Michigan Medicine; U-M Rogel Cancer Center
- Josh J. Sekela🇺🇸University of North Carolina at Chapel Hill
- Joshua B. Simpson🇺🇸University of North Carolina at Chapel Hill
- Matthew R. Redinbo🇺🇸University of North Carolina at Chapel Hill
- Al Wilson🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Shahid Umar🇺🇸University of Kansas Medical Center
- Christie A. Befort🇺🇸University of Kansas Medical Center
- Bruce F. Kimler🇺🇸University of Kansas Medical Center
- Stephen David Hursting🇺🇸University of North Carolina at Chapel Hill
- Carol J. Fabian🇺🇸University of Kansas Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Obesity is associated with gut dysbiosis, chronic inflammation, and insulin resistance. We assessed the proportional change in fecal microbial populations in a pilot study (n = 34) of peri/postmenopausal women with a body mass index ≥28 kg/m2 who were randomized to receive either 3.25 g/day of omega-3 fatty acids or a placebo during a weight loss intervention. Body composition was assessed using dual X-ray absorptiometry, and fecal and blood samples were collected. The median weight change was -10%. Among participants who lost ≥10% of their weight, those assigned to omega-3 fatty acids showed the greatest decrease in the Firmicutes:Bacteroidetes ratio and displayed favorable changes in systemic biomarkers. Notable increases in the proportional abundance of short-chain fatty acid (SCFA)-producing microbes including Phocaeicola vulgatus and Alistipes putredinis were observed in women receiving omega-3, which correlated with improvements in breast cancer biomarkers such as bioavailable estradiol, adiponectin:leptin ratio, and C-reactive protein levels. Women administered omega-3 fatty acids displayed increased % change in plasma SCFA propionate and decreased butyrate, suggesting that intervention differentially modulated circulating bacteria-derived SCFA metabolites. High-dose omega-3 fatty acids, when added to a behavioral weight loss intervention, promoted beneficial shifts in the gut microbiome and associated with improved breast cancer risk factor biomarkers.
Prevention relevance
Obesity is a modifiable risk factor for breast cancer, characterized by chronic inflammation and altered adipokines. This trial addresses the need to enhance weight loss by targeting underlying metabolic and inflammatory drivers. We show that omega-3 polyunsaturated fatty acids (eicosapentaenoic acid/docosahexaenoic acid) shift SCFA-producing microbiota, increase propionate, and correlate with improved breast cancer risk factor biomarkers.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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