Financiado en parte por Egg Nutrition Center
Egg Intake and the Incidence of Alzheimer's Disease in the Adventist Health Study-2 Cohort Linked with Medicare Data
Oh J, Oda K, Chiriac G, Fraser GE, Sirirat R, Sabaté J
The Journal of nutrition · 1 cita
Etiquetas de revisión
Cuestionario de frecuencia de consumoFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Egg Nutrition Center
- Gobierno
- National Cancer Institute
- Gobierno
- National Institutes of Health National Cancer Institute
- Subvenciones
- National Cancer Institute (1U01CA152939)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-04-17 · J Nutr · vol. 156 · número 6 · pág. 101541
- Editorial
- Elsevier BV
- Citado
- 2 citas · más que el 99% de estudios similares · 15.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Food composition and properties · Alzheimer's disease research and treatments
- Palabras clave
- Hazard ratio, Proportional hazards model, Cohort, Incidence (geometry), Cohort study, Disease, Confidence interval, Prospective cohort study, Nutrient
- MeSH
- humans, alzheimer disease, diet, incidence, proportional hazards models, risk factors, cohort studies, prospective studies, life style, eggs, aged, aged, 80 and over, medicare, united states, female, male
6 autores
- Jisoo Oh🇺🇸 · autor de correspondenciaLoma Linda University; Loma Linda University Health Care
- Keiji Oda🇺🇸Loma Linda University; Loma Linda University Health Care
- Gabriela Chiriac🇺🇸Loma Linda University; Loma Linda University Health Care
- Gary E. Fraser🇺🇸Loma Linda University; Loma Linda University Health Care
- Rawiwan Sirirat🇺🇸Loma Linda University; Loma Linda University Health Care
- Joan Sabaté🇺🇸Loma Linda University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A substantial knowledge gap remains regarding the relationship between modifiable dietary factors and Alzheimer's disease risk. Eggs are a source of key nutrients that support brain health.
Objectives
The aim of this study was to investigate the association between egg consumption and the incidence of Alzheimer's disease.
Methods
Data were drawn from the Adventist Health Study-2, a large, prospective cohort of United States Seventh-day Adventists, linked with Medicare records to identify Alzheimer's disease diagnosis. Diet and lifestyle factors were assessed using a validated food frequency questionnaire. Egg consumption was categorized by frequency, ranging from never/rarely to ≥5 times per week. The analytic sample included 39,498 participants (mean follow-up: 15.3 y), among whom 2858 developed Alzheimer's disease. Multivariable-adjusted Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic spline analysis was conducted using continuous egg intake (g/d).
Results
Egg consumption was inversely associated with Alzheimer's disease risk. Compared with never/rarely consuming eggs, HRs (95% CIs) after adjusting for demographic, lifestyle, food groups, and comorbidities were 0.83 (0.75, 0.92) for 1-3 times per month, 0.83 (0.74, 0.94) for once per week, 0.80 (0.71, 0.90) for 2-4 times per week, and 0.73 (0.60, 0.89) for ≥5 times per week. In the spline model, zero egg intake was curvilinearly associated with an adjusted HR of 1.22 (1.11, 1.34) compared with 10 g/d.
Conclusions
In this health-conscious population, moderate egg consumption was associated with a significantly lower risk of Alzheimer's disease. These findings suggest a potential neuroprotective benefit of nutrients found in eggs when consumed as part of a balanced diet.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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