Circulating Piwi-Interacting RNAs Associate With Childhood Asthma ICS Response With Vitamin D Effect Modification
Li J, Hong X, Chi M, Kho AT, Zhu Z, Zhang H, Liu T, McGeachie MJ, Celedón JC, Weiss ST, Tantisira KG, Li J
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Organización sin fines de lucro
- Guangdong Medical Research Foundation
- Gobierno
- National Institutes of Health
- Gobierno
- Sanming Project of Medicine in Shenzhen
- Gobierno
- Shenzhen Science and Technology Innovation Program
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NIH HHS
- Gobierno
- Sanming Project of Medicine in Shenzen Municipality
- Universidad u hospital
- Seventh Affiliated Hospital of Sun Yat-Sen University
- Subvenciones
- National Natural Science Foundation of China (82570048); Shenzhen Science and Technology Innovation Program (JCYJ20250604143521027); National Heart, Lung, and Blood Institute (R01HL127332); Guangdong Medical Research Foundation (A2024136); Shenzhen Science and Technology Innovation Program (JCYJ20240813150456074); National Heart, Lung, and Blood Institute (R01HL162570); Shenzhen Science and Technology Innovation Program (JCYJ20230807110302006); Sanming Project of Medicine in Shenzhen (SZSM202411013); National Institutes of Health (R01 HL139634); National Institutes of Health (R01 HL129935); National Institutes of Health (R01 HL161362)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2026-04-20 · Clin Exp Allergy · vol. 56 · número 10 · págs. 1215–1223
- Editorial
- Wiley
- Citado
- 0 citas · más que el 25% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Asthma and respiratory diseases · Vitamin D Research Studies · Allergic Rhinitis and Sensitization
- Palabras clave
- piRNA, childhood asthma, inhaled corticosteroids, vitamin D deficiency, effect modification, FEV1, bronchial epithelial cells, type 2 asthma
- MeSH
- humans, asthma, adrenal cortex hormones, vitamin d, rna, small interfering, administration, inhalation, child, female, male, biomarkers, piwi-interacting rna
14 autores
- Li Jiang🇺🇸🇨🇳Brigham and Women's Hospital; Harvard University; Sun Yat-sen University; The Seventh Affiliated Hospital of Sun Yat-sen University; Shenzhen University of Advanced Technology
- Li Jiang🇺🇸🇨🇳 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; Sun Yat-sen University; The Seventh Affiliated Hospital of Sun Yat-sen University; Shenzhen University of Advanced Technology
- Xiaoning Hong🇨🇳Sun Yat-sen University; The Seventh Affiliated Hospital of Sun Yat-sen University
- Mengshi Chi🇨🇳Sun Yat-sen University; The Seventh Affiliated Hospital of Sun Yat-sen University
- Alvin T. Kho🇺🇸Brigham and Women's Hospital; Boston Children's Hospital; Harvard University
- Zhongxu Zhu🇨🇳Chinese Academy of Sciences; Hangzhou Institute of Medicine, Chinese Academy of Sciences
- Hui Zhang🇭🇰Hong Kong Polytechnic University
- Tao Liu🇨🇳First Affiliated Hospital of Guangzhou Medical University; State Key Laboratory of Respiratory Disease; Guangzhou Institute of Respiratory Health
- Michael J. McGeachie🇺🇸Brigham and Women's Hospital; Harvard University
- Juan C. Celedón🇺🇸University of Pittsburgh
- Scott T. Weiss🇺🇸Brigham and Women's Hospital; Harvard University
- Kelan G. Tantisira🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; University of California San Diego
- Jiang Li🇺🇸🇨🇳 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; Sun Yat-sen University; The Seventh Affiliated Hospital of Sun Yat-sen University; Shenzhen University of Advanced Technology
- Jiang Li🇺🇸🇨🇳Brigham and Women's Hospital; Harvard University; Sun Yat-sen University; The Seventh Affiliated Hospital of Sun Yat-sen University; Shenzhen University of Advanced Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Piwi-interacting RNAs (piRNAs) have been linked to type 2-high asthma phenotypes. Although vitamin D modulates inhaled corticosteroid (ICS) response via microRNAs, its potential role through piRNAs remains unknown.
Methods
Baseline plasma piRNA expression was profiled by small RNA sequencing in 492 participants from the Childhood Asthma Management Program (CAMP), with 187 children randomised to the ICS arm. Serum vitamin D levels were classified as insufficient (≤ 30 ng/mL) or sufficient (> 30 ng/mL). Linear regression was used to assess associations between piRNA expression and changes in prebronchodilator percent predicted forced expiratory volume in 1 s (FEV1%) over 4 years, including interaction analyses with vitamin D status. Replication was performed in 375 ICS-treated participants from the Genetics of Asthma in Costa Rica Study (GACRS).
Results
Fourteen piRNAs were significantly associated with FEV1% changes among vitamin D-insufficient children, six showing significant interactions with vitamin D status (p < 0.05). Four piRNAs were replicated in GACRS, with piR-36241 also confirmed in interaction analyses. Predicted targets of piR-36241 were enriched in immune- and respiratory-related pathways. piR-36241 demonstrated strong predictive performance for ICS response in vitamin D-insufficient children (AUROC = 0.84) and was detected in bronchial epithelial cells, where it was differentially expressed in asthma.
Conclusions
Circulating piRNAs are associated with ICS response in childhood asthma, with vitamin D acting as an effect modifier, which may serve as non-invasive biomarkers for ICS responsiveness, particularly in vitamin D-insufficient patients.
Trial registration
ClinicalTrials.gov Identifier: NCT00000575 and NCT00021840.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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