Ultraprocessed food intake and postmenopausal breast cancer risk in the NIH-AARP Diet and Health Study
O'Connell CP, Burns KF, Hong HG, Kahle L, Liao LM, Madrigal JM, Rising CJ, Sinha R, Khandpur N, Martínez Steele E, Gierach G, Loftfield E
Journal of the National Cancer Institute · 0 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- National Institutes of Health
- Gobierno
- Intramural Research Program of the National Institutes of Health
- Gobierno
- US Department of Health and Human Services
- Gobierno
- NIH
Según 5 financiadores declarados.
Publicación
- Publicado
- 2026-04-17 · J Natl Cancer Inst
- Editorial
- Oxford University Press
- Citado
- 1 cita · más que el 96% de estudios similares · 7.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · PUBLIC-DOMAIN
- Áreas de investigación
- Nutritional Studies and Diet · Cancer Risks and Factors · Consumer Attitudes and Food Labeling
- Palabras clave
- Breast cancer, Food intake, Postmenopausal women, Cancer, Alcohol intake, Cohort study, Body mass index
12 autores
- Caitlin P. O’Connell🇺🇸National Cancer Institute; Department of Health and Human Services
- Kaelyn F Burns🇺🇸National Cancer Institute; Department of Health and Human Services
- Hyokyoung G. Hong🇺🇸National Cancer Institute; Department of Health and Human Services
- Lisa Kahle🇺🇸Information Management Services
- Linda M. Liao🇺🇸National Cancer Institute; Department of Health and Human Services
- Jessica M. Madrigal🇺🇸Illinois Department of Public Health; National Cancer Institute; Department of Health and Human Services; University of Illinois at Springfield
- Camella J. Rising🇺🇸National Cancer Institute; Department of Health and Human Services
- Rashmi Sinha🇺🇸National Cancer Institute; Department of Health and Human Services
- Neha Khandpur🇳🇱Wageningen University & Research
- Eurídice Martínez Steele🇧🇷Universidade de São Paulo
- Gretchen Gierach🇺🇸National Cancer Institute; Department of Health and Human Services
- Erikka Loftfield🇺🇸 · autor de correspondenciaNational Cancer Institute; Department of Health and Human Services
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ultraprocessed food (UPF) intake is associated with obesity. Despite obesity being a risk factor for postmenopausal breast cancer, evidence for an association between UPF and breast cancer is limited. Our objective was to assess the association between UPF intake and postmenopausal breast cancer risk in the NIH-AARP Diet and Health Study.
Methods
Participants reported dietary intake via a food frequency questionnaire at baseline in 1995-1996 and were followed through 2018. Food items were disaggregated into food codes and assigned Nova classification via database linkage. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for quintiles of UPF (g (1000 kcal day-1)-1) and postmenopausal breast cancer risk overall, by estrogen receptor (ER) status, and type (invasive or ductal carcinoma in situ [DCIS]), with and without adjustment for body mass index (BMI).
Results
Among 181 460 postmenopausal women, 14 484 were diagnosed with breast cancer over a median 21 years of follow-up. Median (interquartile range) UPF intake was 284.6 (191.1-466.6) g (1000 kcal day-1)-1. No associations between UPF intake and postmenopausal breast cancer risk overall (HRQ5 vs Q1 = 0.98, 95% CI = 0.93 to 1.03; P = .32 for trend), by ER status (ER+: HRQ5 vs Q1 = 1.01, 95% CI = 0.94 to 1.09; P = .95 for trend; ER-: HRQ5 vs Q1 = 1.02, 95% CI = 0.87 to 1.20; P = .58 for trend), or by type (invasive: HRQ5 vs Q1 = 0.98, 95% CI = 0.92 to 1.04; P = .14 for trend; DCIS HRQ5 vs Q1 = 1.00, 95% CI = 0.87 to 1.13; P = .26 for trend) were observed. Following BMI adjustment, inverse trends for overall (P = .03 for trend) and invasive (P = .01 for trend) breast cancer were observed.
Conclusion(s)
UPF intake was not associated with postmenopausal breast cancer in the NIH-AARP cohort. Inverse trends observed after adjusting for BMI are likely spurious, owing to overadjustment.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.