Repeated low-level red-light therapy for improving asthenopic symptoms and accommodation in presbyopia
Song F, Zhao Z, Zhang J, Li J, Wu Y, Liu Y, Li P, Wang Y, Lai M, He M, Chen Y
Annals of medicine · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Hong Kong Polytechnic University
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Hong Kong Polytechnic University (P0046113)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-04-28 · Ann Med · vol. 58 · número 1 · pág. 2663105
- Editorial
- Informa
- Citado
- 0 citas · más que el 35% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Spatial Neglect and Hemispheric Dysfunction · Ergonomics and Musculoskeletal Disorders
- Palabras clave
- Presbyopia, Blinding, Randomization, Accommodation, Randomized controlled trial, Adverse effect, Near vision, Refractive error
- MeSH
- humans, asthenopia, presbyopia, treatment outcome, double-blind method, visual acuity, accommodation, ocular, adult, middle aged, female, male, surveys and questionnaires, low-level light therapy, red light
11 autores
- Fan Song🇭🇰Hong Kong Polytechnic University
- Ziwei Zhao🇭🇰Hong Kong Polytechnic University
- J Q Zhang🇨🇳Sun Yat-sen University
- Jijing Li🇦🇺Vision Eye Institute
- Yue Wu🇭🇰Hong Kong Polytechnic University
- Ying Liu🇭🇰Hong Kong Polytechnic University
- Pengju Li🇭🇰Hong Kong Polytechnic University
- Yueye Wang🇭🇰Hong Kong Polytechnic University
- Mengying Lai🇭🇰Hong Kong Polytechnic University
- Mingguang He🇭🇰🇦🇺 · autor de correspondenciaHong Kong Polytechnic University; Vision Eye Institute
- Yanxian Chen🇭🇰 · autor de correspondenciaHong Kong Polytechnic University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
To assess the short-term effectiveness of repeated low-level red light (RLRL) therapy in relieving asthenopia and enhancing accommodation in presbyopia.
Methods
This randomized, parallel-group, double-masked clinical trial enrolled adults with presbyopia and self-reported asthenopia. Participants were allocated using computer-generated randomization and randomly assigned at a 1:1 ratio to RLRL or sham groups. Blinding included participants, examiners, assessors, and statisticians. The primary outcome was the change from baseline in the Computer Vision Syndrome Questionnaire (CVS-Q) score at day 31. Secondary outcomes were the change in accommodative amplitude (AA), Near Activity Visual Questionnaire (NAVQ) score, habitual near visual acuity, near-addition power, accommodative facility, positive and negative relative accommodation, binocular cross-cylinder response, and accommodative convergence-to-accommodation ratio. Continuous outcomes were analyzed using linear mixed-effects models.
Results
Sixty-four of 66 randomized participants (aged 41-62 years) completed the 1-month trial. At day 31, RLRL showed greater improvement than sham in CVS-Q score (adjusted mean difference, -1.75 points; 95% CI, -3.10 to -0.39), binocular AA (1.09 D; 95% CI, 0.37 to 1.82), and NAVQ score (-8.07 points; 95% CI, -14.17 to -1.97). The effect on AA was most pronounced in a subgroup of eyes with baseline amplitude >2.0 D (adjusted mean difference 1.33 D; 95% CI 0.32-2.34). Other measures did not differ between groups at each visit. No treatment-related adverse events were reported. Adherence was similar between groups (mean compliance: 98.2% vs 97.5%).
Conclusions
Short-term treatment with RLRL significantly reduced asthenopic symptoms and improved accommodative amplitude in individuals with presbyopia.Trial registration: NCT06745661 (registered December 8, 2024).
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