Efficacy and Safety of High-Dose Vitamin D Supplementation Combined With an Enuresis Alarm vs Alarm Alone in Children With Primary Monosymptomatic Nocturnal Enuresis: A Randomized Clinical Trial
Ye Z, Luo X, Chen H, Zhang Q, Li C, Zhang Z, Wu S, Zhang D, Hua Y, Wei G, Liu X
The Journal of urology · 0 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-04-29 · J Urol · vol. 216 · número 2 · págs. 182–193
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 0 citas · más que el 26% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Pediatric Urology and Nephrology Studies · Urinary Bladder and Prostate Research · Vitamin D Research Studies
- Palabras clave
- primary monosymptomatic nocturnal enuresis, vitamin D supplementation, vitamin D insufficiency, 25-hydroxyvitamin D, children, treatment response, quality of life, treatment satisfaction, adverse events
- MeSH
- humans, vitamins, vitamin d, treatment outcome, combined modality therapy, quality of life, dietary supplements, child, female, male, nocturnal enuresis, clinical alarms
11 autores
- Zihan Ye🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- X H Luo🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Hongsong Chen🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Qiang Zhang🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Chang Li🇨🇳Children's Hospital of Chongqing Medical University
- Z Zhang🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Shengde Wu🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Deying Zhang🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Yi Hua🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Guanghui Wei🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Xing Liu🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This study evaluated the efficacy and safety of high-dose vitamin D supplementation (VDS) combined with enuresis alarm (EA) therapy in children with primary monosymptomatic nocturnal enuresis (PMNE).
Materials and methods
A 2-arm randomized clinical trial was conducted at a tertiary center in China between December 2024 and May 2025. Children with PMNE and serum 25-hydroxyvitamin D levels below 30 ng/mL were randomly assigned to receive either 8 weeks of VDS (vitamin D3 soft capsules, 2400 IU/d) plus EA (VDS + EA group) or EA (EA group). The primary outcome was treatment response. Secondary outcomes included change in weekly frequency of wet nights, quality of life scores, and treatment satisfaction. Safety was assessed by recording treatment-emergent adverse events.
Results
A total of 304 children were assessed for eligibility, of whom 262 (130 in the VDS + EA group and 132 in the EA group) were included in the final analysis. Compared with the EA group, the VDS + EA group showed higher response rates (RR 1.22; 95% CI 1.01-1.49; P = .04), complete response rates (RR 1.54; 95% CI 1.10-2.15; P = .01), a greater reduction in weekly wet nights (median difference, 1; 95% CI, 0-2; P = .003), and greater improvements in quality of life and treatment satisfaction. No statistically significant difference in the risk of treatment-emergent adverse events was observed between groups.
Conclusions
High-dose VDS combined with EA was effective and well tolerated for treating PMNE in children with vitamin D insufficiency, supporting its potential as a promising therapeutic approach.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.