Effect of Polyphenol-Rich Diet Combined with Leucine, Vitamin D3, and Magnesium Supplementation on Self-Reported Mobility and Health Perception in Adults at Risk of Sarcopenia: A 3-Months Quasi-Experimental Study
Tache-Codreanu DL, Tache-Codreanu AM, Stefan G, Trăistaru MR, Rusu E, Tache-Codreanu A, Sporea C
Life (Basel, Switzerland) · 1 cita
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-03-27 · Life (Basel) · vol. 16 · número 4 · pág. 554
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 1 cita · más que el 93% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutrition and Health in Aging · Muscle Physiology and Disorders · Muscle metabolism and nutrition
- Palabras clave
- Context (archaeology), Sarcopenia, Rehabilitation, Vitamin D and neurology, Muscle strength, Correlation, Perception, Vitamin, Vitamin C
9 autores
- Diana-Lidia Tache-Codreanu🇷🇴Titu Maiorescu University; Spitalul Clinic Colentina
- Ana-Maria Tache-Codreanu🇷🇴Carol Davila University of Medicine and Pharmacy; National University of Theatre and Film I.L. Caragiale
- Ana-Maria Tache-Codreanu🇷🇴 · autor de correspondenciaCarol Davila University of Medicine and Pharmacy; National University of Theatre and Film I.L. Caragiale
- Georgeta Stefan🇷🇴 · autor de correspondenciaUniversity of Agronomic Sciences and Veterinary Medicine of Bucharest
- Magdalena Rodica Trăistaru🇷🇴University of Medicine and Pharmacy of Craiova
- Elena Emanuela Rusu🇷🇴Titu Maiorescu University
- Andrei Tache-Codreanu🇷🇴 · autor de correspondenciaCarol Davila University of Medicine and Pharmacy; National University of Theatre and Film I.L. Caragiale
- Andrei Tache-Codreanu🇷🇴Carol Davila University of Medicine and Pharmacy; National University of Theatre and Film I.L. Caragiale
- Corina Sporea🇷🇴Carol Davila University of Medicine and Pharmacy
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Sarcopenia is characterized by progressive muscle weakness, impaired physical function, and reduced quality of life. Multimodal strategies combining rehabilitation and nutritional support that influence gut microbiota may help improve functional outcomes in adults at risk of sarcopenia.
Objective
To evaluate whether a polyphenol-rich dietary recommendation associated with a nutritional supplement containing leucine, vitamin D3, and magnesium (SarcoDYN®), in the context of a standardized rehabilitation program, provides superior improvements in functional and patient-reported outcomes compared with rehabilitation alone.
Methods
This quasi-experimental, non-randomized retrospective study included 28 adults at risk of sarcopenia, divided into a study group (rehabilitation + polyphenol-rich diet + SarcoDYN®) and a control group (rehabilitation only). Assessments were performed at baseline and after 3 months. Outcomes included SARC-F score, handgrip strength (dominant and non-dominant), sit-to-stand performance, perceived mobility, and perceived health status. Within- and between-group comparisons were conducted using appropriate parametric or non-parametric tests, and Spearman correlation analysis explored associations between functional, strength, and perceptual variables.
Results
Both groups demonstrated significant within-group improvements in functional and patient-reported outcomes. At follow-up, the study group showed significantly better subjective outcomes, including lower SARC-F scores (U = 30.0, p = 0.002), higher perceived mobility (U = 40.0, p = 0.008), and higher perceived health status (U = 40.0, p = 0.008), compared with the control group. Objective post-intervention measures of handgrip strength and chair-rise performance did not differ significantly between groups. Correlation analysis revealed strong associations between SARC-F score, muscle strength, functional mobility, and perceived health.
Conclusions
The combined intervention consisting of a polyphenol-rich diet that influence gut microbiota and SarcoDYN® supplementation, delivered alongside a structured rehabilitation program, was associated with better patient-reported mobility and health perception in adults at risk of sarcopenia. These findings should be considered exploratory and hypothesis-generating, and require confirmation in larger controlled studies.
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