Intermittent fasting for rheumatic diseases: a systematic review and meta-analysis of conflicting evidence from observational studies and randomized controlled trials
Liu R, Zhang C, Li Y, Huang C
PeerJ · 1 cita
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (82574970)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-04-27 · PeerJ · vol. 14 · pág. e21185
- Editorial
- PeerJ, Inc.
- Citado
- 1 cita · más que el 86% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Inflammatory Bowel Disease · Rheumatoid Arthritis Research and Therapies
- Palabras clave
- Observational study, Randomized controlled trial, Rheumatoid arthritis, Cochrane Library, Meta-analysis, Intermittent fasting, Clinical trial, Systematic review
- MeSH
- humans, arthritis, rheumatoid, rheumatic diseases, randomized controlled trials as topic, observational studies as topic, intermittent fasting
4 autores
- Ruofan Liu🇨🇳Anhui University of Traditional Chinese Medicine
- Chuanwei Zhang🇨🇳Anhui University of Traditional Chinese Medicine
- Yunfei Li🇨🇳Anhui University of Traditional Chinese Medicine
- Chuanbing Huang🇨🇳Anhui University of Traditional Chinese Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Intermittent fasting (IF) has emerged as a dietary approach with potential therapeutic effects that is gaining recognition. Although several studies have explored the impact of IF on clinical symptoms in patients with rheumatic diseases, a quantitative synthesis of the existing evidence is lacking. This study aims to systematically evaluate the overall effects of IF on disease activity and inflammatory markers in patients with rheumatic diseases.
Methods
A systematic search was conducted in PubMed, Web of Science, Embase, and The Cochrane Library for clinical studies examining intermittent fasting interventions in rheumatic diseases, with a search deadline of March 15, 2026. RevMan 5.4 software was utilized to perform a meta-analysis on the studies that met the inclusion criteria.
Results
A total of seven independent studies (yielding nine datasets) were included in the analysis, comprising 471 patients with rheumatoid arthritis (RA) and 85 patients with spondyloarthritis (SpA). The results indicated that observational studies, which provide a lower level of evidence, demonstrated significant improvements in disease activity scores associated with intermittent fasting (e.g., Visual Analog Scale (VAS), P P P = 0.04).
Conclusion
These findings suggest a positive effect of intermittent fasting on disease activity, as indicated by both observational studies and RCTs. However, the reliability of the conclusions drawn from RCTs is limited due to the small number of studies and considerable heterogeneity in the interventions. There is an urgent need for more rigorously designed RCTs to further validate these results.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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