The effectiveness of 5:2 intermittent fasting compared with continuous caloric restriction in the treatment of recurrent weight gain after metabolic bariatric surgery: A non-inferiority, short-term, pilot feasibility study
Henao-Carrillo DC, Forero AM, Gómez AM, Robledo S, Pinzón F, Mikler R, Yepes C, Muñoz-Velandia O
Clinical nutrition ESPEN · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-05-05 · Clin Nutr ESPEN · vol. 74 · pág. 103316
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 92% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Dietary Effects on Health · Bariatric Surgery and Outcomes · Diet and metabolism studies
- Palabras clave
- bariatric surgery, weight loss, non-inferiority, medication adherence, body composition, metabolic profile, obesity
- MeSH
- humans, obesity, recurrence, weight gain, weight loss, body mass index, treatment outcome, caloric restriction, fasting, feasibility studies, pilot projects, adult, middle aged, female, male, bariatric surgery, intermittent fasting
8 autores
- Diana Cristina Henao🇨🇴 · autor de correspondenciaPontificia Universidad Javeriana; Hospital Universitario San Ignacio
- Ana Milena Forero🇨🇴 · autor de correspondenciaHospital Universitario San Ignacio
- Ana María Gómez Medina🇨🇴 · autor de correspondenciaPontificia Universidad Javeriana; Hospital Universitario San Ignacio
- Sofìa Robledo🇨🇴 · autor de correspondenciaPontificia Universidad Javeriana; Hospital Universitario San Ignacio
- Fabio Eduardo Pinzón🇨🇴 · autor de correspondenciaHospital Universitario San Ignacio
- Rami Mikler🇨🇴 · autor de correspondenciaHospital Universitario San Ignacio
- Carlos Yepes🇨🇴 · autor de correspondenciaHospital Universitario San Ignacio
- Óscar Múñoz🇨🇴 · autor de correspondenciaPontificia Universidad Javeriana; Hospital Universitario San Ignacio
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Intermittent fasting (IF) is a form of calorie restriction that has recently gained notoriety. However, there is currently no data on its effectiveness for patients with recurrent weight gain (RWG) after metabolic bariatric surgery (MBS).
Methods
A randomized non-inferiority, short-term, pilot feasibility trial was conducted to evaluate the effectiveness of 5:2 intermittent fasting (IF) (75% caloric restriction on two days per week) compared with continuous caloric restriction (CCR) (25% divided into three meals) over 12 weeks, in patients with RWG who had undergone MBS.
Results
Twenty patients were included (mean age 53 ± 9.5 years, body mass index 32.4 ± 3.5 kg/m2). The CCR group showed no change in weight at 12 weeks (mean difference -0.88 kg; 95% CI: -2.2 to 3.9 kg; p = 0.51), whereas the 5:2 IF group experienced an average weight loss of -1.025 kg (95% CI: -0.09 to -1.96 kg; p = 0.03). The difference between the two groups remained within the predefined non-inferiority margin of 4 kg (-0.13; 95% CI: -2.90 to 2.62). No differences in body composition or metabolic profile measurements were observed in either group compared to baseline values. The caloric intake was lower and the treatment adherence higher in the IF group. No serious adverse events occurred during follow-up.
Conclusion
The 5:2 IF appears non-inferior to CCR at 12 weeks, suggesting it could be a promising dietary strategy for RWG. Further research with extended follow-up is essential to assess long-term feasibility, safety, and adherence. Such data will be crucial in establishing the clinical utility and practical implementation of this intervention in RWG management.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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