Effects of Time-Restricted Eating on Gut Microbiota and Metabolites and Their Relationship With Cardiometabolic Risk Factors
Zhang LM, Wang ZD, Zhang Z, Liu J, Li ZH, Ren YR, Liu Z, Zhang X, Wang XY, Qi KX, Yuan C, Guo H, Zhang YF, Ge J, Ma YX
Obesity (Silver Spring, Md.) · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Natural Science Foundation of Hebei Province
- Gobierno
- Science Research Project of Hebei Education Department
- Universidad u hospital
- Postdoctoral Fund of Hebei Medical University
- Subvenciones
- Natural Science Foundation of Hebei Province (H2025206687)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2026-05-08 · Obesity (Silver Spring) · vol. 34 · número 6 · págs. 1289–1299
- Editorial
- Wiley
- Citado
- 1 cita · más que el 93% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Gut microbiota and health · Gastrointestinal motility and disorders
- Palabras clave
- time-restricted eating, gut microbiota, serum metabolites, cardiometabolic risk factors, overweight, weight loss, Faecalibacterium, Lactobacillus, L-malic acid, isovaleric acid, systolic blood pressure, fat mass
- MeSH
- humans, obesity, rna, ribosomal, 16s, risk factors, blood pressure, adult, female, male, overweight, young adult, gastrointestinal microbiome, cardiometabolic risk factors, intermittent fasting
15 autores
- Li‐Min Zhang🇨🇳Hebei Medical University
- Zi-Dan Wang🇨🇳Hebei Medical University
- Zheng Zhang🇨🇳Hebei Medical University; First Affiliated Hospital of Hebei Medical University
- Jie Liu🇨🇳Hebei Medical University
- Z Li🇨🇳Hebei Medical University
- Yue‐Rong Ren🇨🇳Hebei Medical University
- Zhan Liu🇨🇳Hebei Medical University
- Xiao Zhang🇨🇳Hebei Medical University; First Affiliated Hospital of Hebei Medical University
- Xianyun Wang🇨🇳Hebei Medical University; First Affiliated Hospital of Hebei Medical University
- Ke‐Xin Qi🇨🇳Hebei Medical University
- Chang Yuan🇨🇳Hebei Medical University
- Hao Guo🇨🇳Hebei Medical University
- Yifei Zhang🇨🇳Hebei Medical University
- J H Ge · autor de correspondencia
- Yu‐Xia Ma🇨🇳 · autor de correspondenciaHebei Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study aimed to investigate whether the time of the eating window during time-restricted eating (TRE) alters the gut microbiota and metabolomic profiles and to determine their relationship with cardiometabolic risk factors in adults with overweight or obesity.
Methods
In an 8-week randomized controlled trial, 60 young adults with overweight or obesity were randomized to 6-h eTRE (7 a.m.-1 p.m.), 6-h lTRE (12 p.m.-6 p.m.), or a control group (ad libitum). The gut microbiota was analyzed by 16S ribosomal RNA (16S rRNA) sequencing and serum metabolomics were quantified by liquid chromatography-mass spectrometry (LC-MS).
Results
After 8 weeks, compared to the control group, the 6-h eTRE increased abundance of Faecalibacterium and Lactobacillus and decreased abundance of unclassified_f_Peptostreptococcaceae, whereas 6-h lTRE significantly increased abundance of Faecalibacterium and decreased abundance of Shigella (all p < 0.05). Differential serum metabolites (e.g., L-malic acid in eTRE; isovaleric acid in lTRE) were significantly associated with changes in weight, body fat, and systolic blood pressure (SBP) (p < 0.05).
Conclusions
Time-restricted eating may be beneficial to weight loss and cardiometabolic health improvement by regulating gut microbiota and serum metabolites.
Trial registration
Chinese Clinical Trial Registry ChiCTR2000039115.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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