The effect of dietary nitrate on weight management: a systematic review and meta-analysis
Cai W, Wei P, Yang F, Shu L, Du Y, Feng H, Shi J, Kang C, Peng X
Frontiers in public health · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-04-28 · Front Public Health · vol. 14 · pág. 1798811
- Editorial
- Frontiers Media
- Citado
- 0 citas · más que el 25% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Methemoglobinemia and Tumor Lysis Syndrome · Vitamin C and Antioxidants Research
- Palabras clave
- Blood pressure, Body mass index, Nitrate, Randomized controlled trial, Obesity, Weight loss, Body weight, Meta-analysis
- MeSH
- humans, obesity, nitrates, body mass index, blood pressure, dietary supplements, randomized controlled trials as topic
9 autores
- Wenjun Cai
- Peng Wei🇲🇴Macau University of Science and Technology
- Fan Yang🇨🇳Chengdu Medical College
- Lin Shu
- Y Q DU🇨🇳Chengdu Medical College
- Huirong Feng🇨🇳Chengdu Medical College
- Jiaojiao Shi🇮🇳 · autor de correspondenciaCommand Hospital
- Chao Kang🇮🇳 · autor de correspondenciaCommand Hospital
- Xiaoli Peng🇨🇳 · autor de correspondenciaChengdu Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Obesity has emerged as a significant global public health concern. Despite its potential therapeutic benefits, the existing evidence regarding dietary nitrate supplementation remains inconclusive. This systematic review and meta-analysis aimed to evaluate the effects of dietary nitrate intake on obesity-related outcomes.
Methods
A comprehensive search of randomized controlled trials (RCTs) investigating nitrate supplementation in adults with obesity was conducted across PubMed, Scopus, Web of Science, and Embase up to April 2026. The primary outcomes included body weight, body mass index (BMI), blood pressure, and lipid-related markers. The study adhered to the PRISMA 2020 guidelines for reporting.
Results
Eight RCTs involving 199 participants were included in the meta-analysis. No significant effects of nitrate supplementation were observed on body weight, BMI, or diastolic blood pressure (DBP). A statistically significant reduction was observed in systolic blood pressure (SBP, 95% CI: -0.63 to -0.01; SMD = -0.32, p = 0.04; I2 = 41%). In addition, dietary nitrate supplementation was associated with significant reductions in total cholesterol (TC, 95% CI: -1.11 to -0.06; SMD = -0.59, p = 0.03; I2 = 50%) and triglycerides (TG, 95% CI: -0.81 to -0.09; SMD = -0.45, p = 0.01; I2 = 0%). Subgroup analysis stratified by intervention duration revealed no significant interaction effects for either SBP or DBP (all P for interaction > 0.05). Publication bias was detected for BMI and DBP.
Conclusion
Dietary nitrate supplementation exerts favorable effects on lipid parameters and systolic blood pressure, with no remarkable impacts on body weight and BMI observed. Given the relatively small sample size of the included evidence, future large-sample, high-quality, long-term randomized controlled trials are essential to confirm and reinforce the present results.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/, CRD420251078542.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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