Relationships between rest-activity rhythms, cancer-related fatigue, and quality of life: Results from a time-restricted eating randomized controlled trial
Kleckner AS, Zhou Y, Diaz-Mercado Y, Hahn JO, Kleckner IR, Zhu S
Chronobiology international · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Maryland Department of Health
- Gobierno
- Maryland Department of Health’s Cigarette Restitution Fund Program
- Gobierno
- NCI NIH HHS
- Gobierno
- NCATS NIH HHS
- Universidad u hospital
- Institute for Clinical and Translational Research
- Sin clasificar
- Accelerated Translational Incubator Pilot (ATIP) Grant Program
Según 6 financiadores declarados.
Publicación
- Publicado
- 2026-05-14 · Chronobiol Int · vol. 43 · número 9 · págs. 1359–1372
- Editorial
- Taylor & Francis
- Citado
- 2 citas · más que el 96% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Circadian rhythm and melatonin · Cancer survivorship and care · Sleep and related disorders
- Palabras clave
- rest-activity rhythm, cancer-related fatigue, quality of life, cancer survivors, time-restricted eating, actigraphy, hidden Markov models, cosinor analysis, intradaily variability, emotional well-being
- MeSH
- humans, neoplasms, fatigue, circadian rhythm, time factors, quality of life, rest, adult, aged, middle aged, female, male, actigraphy, surveys and questionnaires, intermittent fasting
6 autores
- Amber S. Kleckner🇺🇸 · autor de correspondenciaUniversity of Maryland, Baltimore; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center; University of Maryland, College Park
- Yuanyuan Zhou🇺🇸University of Maryland, College Park
- Yancy J. Diaz-Mercado🇺🇸University of Maryland, College Park
- Jin‐Oh Hahn🇺🇸University of Maryland, College Park
- Ian R. Kleckner🇺🇸University of Maryland, Baltimore; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center; University of Maryland, College Park
- Shijun Zhu🇺🇸University of Maryland, Baltimore; University of Maryland, College Park
Resumen
El texto original del estudio, en el idioma en que se publicó.
Circadian rest-activity rhythms, or a person's consistency in their daily activity and rest patterns, can be quantified using various parametric and non-parametric methods. However, these methods are seldom applied to understand symptoms in cancer survivorship. This study examined associations between various rest-activity rhythm parameters and cancer-related fatigue and quality of life. Adult cancer survivors (n = 31) were enrolled in a 12-week randomized clinical trial of individualized nutrition counseling with or without time-restricted eating. Participants wore actigraphy watches continuously for 3-7 days at baseline, 6 weeks, and 12 weeks. Rest-activity parameters were derived using cosinor models, traditional non-parametric methods, and probabilistic hidden Markov models (HMMs). Participants completed the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire, including physical, social, emotional, and functional well-being subscales; fatigue; and a quality-of-life total score. Mixed models revealed that stronger rest-activity rhythms were generally associated with lower fatigue and greater well-being in several dimensions. Specifically, intradaily variability and the HMM-derived rhythm index were positively associated with emotional well-being (p = 0.040 and p = 0.037, respectively, medium effect sizes). Earlier daily activity peaks, identified through both parametric and non-parametric methods, were linked to greater emotional well-being (e.g. cosinor peak time and emotional well-being, p = 0.006, large effect size; start hour of the most active 10 hours, p = 0.004, large effect size). There was no effect of group (time-restricted eating vs. control) on any of the rest-activity parameters. Findings suggest that rest-activity rhythm parameters, including those derived from novel HMMs, may serve as useful biomarkers of fatigue and various dimensions of well-being, supporting further research in larger samples and potential clinical application.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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