Krill oil increases plasma omega-3 fatty acids more than fish oil in healthy adults: a double-blind randomized controlled trial
Loukil I, Vachon A, Çaku A, Plourde M
The American journal of clinical nutrition · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Canadian Institutes of Health Research
- Universidad u hospital
- Institute of Nutrition, Metabolism and Diabetes
- Universidad u hospital
- Institute of Nutrition Metabolism and Diabetes
- Subvenciones
- Institute of Nutrition, Metabolism and Diabetes (201909PJ)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-05-16 · Am J Clin Nutr · vol. 124 · número 1 · pág. 101346
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 93% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- krill oil, fish oil, omega-3 fatty acids, EPA, docosahexaenoic acid, plasma fatty acid concentrations, APOE ε4, sex differences, dietary supplementation, healthy adults
- MeSH
- animals, humans, euphausiacea, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fish oils, double-blind method, genotype, dietary supplements, adult, middle aged, female, male, apolipoprotein e4, young adult
4 autores
- Insaf Loukil🇨🇦Université de Sherbrooke; Université Laval; Centre de recherche sur le vieillissement; Institut sur la nutrition et les aliments fonctionnels (INAF)
- Annick Vachon🇨🇦Université de Sherbrooke; Université Laval; Centre de recherche sur le vieillissement; Institut sur la nutrition et les aliments fonctionnels (INAF)
- Artuela Çaku🇨🇦Université de Sherbrooke
- Mélanie Plourde🇨🇦 · autor de correspondenciaUniversité de Sherbrooke; Université Laval; Centre de recherche sur le vieillissement; Institut sur la nutrition et les aliments fonctionnels (INAF)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Omega-3 fatty acids (ω-3 FAs), particularly EPA and DHA, are recognized for their health benefits. However, their circulating levels after supplementation may be modulated by several factors, including sex, carriage of the apolipoprotein E ε4 (APOE4) allele, and the chemical form of the supplement. Krill oil delivers ω-3 FAs primarily as phospholipids, whereas fish oil provides them as triglycerides.
Objectives
This study aimed to compare EPA and DHA concentrations after supplementation with krill oil and fish oil and assess whether sex and APOE4 genotype modify responses to supplementation.
Methods
This double-blind, randomized clinical trial included 72 healthy adults (53 females, 19 males) matched for age and BMI. Participants received 1.1 g/d ω-3 FAs through either krill oil (n = 36) or fish oil (n = 36) for 12 wk. Plasma FAs were measured at baseline and at weeks 1, 2, 4, and 12 by GC-flame ionization detection. Differences in plasma ω-3 FAs concentrations by treatment, sex, and APOE4 status were analyzed.
Results
Time-by-treatment interactions were significant for plasma delta over baseline concentrations of EPA (P = 0.0001) and DHA (P = 0.005), with krill oil resulting in ∼1.5-fold higher Δ EPA and Δ DHA compared with fish oil. The time-by-sex interaction was significant only for EPA (P = 0.026), with females having a 1.5-fold greater increase than males at 12 wk. After supplementation with either krill oil or fish oil, APOE4 carriers had 3-fold and 1.6-fold higher EPA and DHA, respectively, compared with baseline; however, these increases were not significantly different from those found in noncarriers.
Conclusions
Krill oil increased plasma ω-3 FAs more than fish oil, regardless of APOE4 genotype. Individuals with higher ω-3 FA requirements may achieve adequate enrichment with lower doses of krill oil compared with fish oil supplementation. This trial was registered at clinicaltrials.gov as NCT04279743.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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