Does creatine affect lipid profile? a systematic review and meta-analysis of randomized placebo-controlled trials
Gimenez FVM, Pasternak N, Santesso L, da Silva LMA, Girotto LA, Candeloro BM, Barbalho SM, Porto AA, Raimundo RD, de Abreu LC, Valenti VE
Frontiers in nutrition · 0 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Universidad u hospital
- Universidade Estadual Paulista
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de São Paulo (25/06769-1)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-05-08 · Front Nutr · vol. 13 · pág. 1787009
- Editorial
- Frontiers Media
- Citado
- 0 citas · más que el 18% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Lipoproteins and Cardiovascular Health · Diet, Metabolism, and Disease
- Palabras clave
- creatine supplementation, lipid profile, triglycerides, total cholesterol, LDL cholesterol, HDL cholesterol, serum lipids, dietary supplements
11 autores
- Fabiana Veronez Martelato Gimenez🇧🇷Faculdade de Medicina de Marília; Universidade Estadual Paulista (Unesp)
- Natalia Pasternak🇺🇸Columbia University
- Lívia Santesso🇧🇷Universidade Estadual Paulista (Unesp)
- Lívia M. A. da Silva🇧🇷Universidade Estadual Paulista (Unesp)
- Lara A. Girotto🇧🇷Universidade Estadual Paulista (Unesp)
- Bruno Moreira Candeloro🇧🇷Universidade Estadual Paulista (Unesp)
- Sandra Maria Barbalho🇧🇷Faculdade de Medicina de Marília; Universidade de Marília; Universidade Estadual Paulista (Unesp)
- Andrey A. Porto🇧🇷Universidade Estadual Paulista (Unesp)
- Rodrigo Daminello Raimundo🇧🇷Faculdade de Medicina do ABC; Universidade Estadual Paulista (Unesp)
- Luiz Carlos de Abreu🇮🇪🇧🇷University of Limerick; Universidade Federal do Espírito Santo; Universidade Estadual Paulista (Unesp)
- Vitor E. Valenti🇧🇷Universidade Estadual Paulista (Unesp)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Creatine, recognized for its regulatory functions in various metabolic tissues, has aroused interest regarding its systemic effects. This study aimed to evaluate the impact of creatine supplementation on blood lipid profile parameters.
Methods
A systematic review with meta-analysis was conducted following the PRISMA guidelines (CRD420251025690). Searches were conducted in EMBASE, Lilacs, CINAHL, MEDLINE/PubMed, Cochrane, Scopus, and Web of Science databases up to June 2025. Randomized clinical trials involving adults receiving oral creatine supplementation versus placebo were included. The outcomes analyzed included triglycerides, total cholesterol, low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-c). Risk of bias was assessed using the Cochrane RoB 2 tool, and certainty of evidence was assessed using the GRADE system.
Results
We selected 8 RCTs. Pooled analyses demonstrated no statistically significant effects of creatine supplementation on total cholesterol (MD: 2.9 mg/dL; 95% CI: -7.44 to 13.24; I2 = 46%), LDL-C cholesterol (MD: 4.08 mg/dL; 95% CI: -2.55 to 10.70; I2 = 8%), HDL-C (MD: -0.68 mg/dL; 95% CI: -3.94 to 2.59; I2 = 0%), or triglycerides (MD: 7.95 mg/dL; 95% CI: -13.73 to 29.63; I2 = 55%). The certainty of evidence was classified as very low for total cholesterol and triglycerides and low for LDL-C and HDL-C. Methodological limitations were identified in the randomization and reporting of results processes.
Conclusion
Creatine supplementation did not demonstrate clinically relevant effects on lipid profiles. Future studies with greater methodological rigor and larger samples are recommended for definitive confirmation of these findings.
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