Effect of low-level laser therapy versus calcium hydroxide intra-canal medication on postoperative pain and inflammatory mediator reduction in symptomatic apical periodontitis: a randomized clinical trial
Otaify RR, Abouelenien SS, Ghoneim AG, Shaker OG
BMC oral health · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Cairo University
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-05-25 · BMC Oral Health · vol. 26 · número 1
- Editorial
- BioMed Central
- Citado
- 0 citas · más que el 33% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Endodontics and Root Canal Treatments · Laser Applications in Dentistry and Medicine · Periodontal Regeneration and Treatments
- Palabras clave
- low-level laser therapy, calcium hydroxide, intracanal medicaments, symptomatic apical periodontitis, postoperative pain, interleukin-8, substance P, endodontic treatment, single-visit treatment, inflammatory mediators, periapical inflammation
- MeSH
- humans, periapical periodontitis, calcium hydroxide, substance p, inflammation mediators, interleukin-8, pain measurement, treatment outcome, adult, middle aged, female, male, young adult, low-level light therapy, postoperative pain
4 autores
- Radhwa Refaat Otaify🇪🇬 · autor de correspondenciaCairo University
- Sarah Samir Abouelenien🇪🇬Cairo University
- Angie Galal Ghoneim🇪🇬Cairo University
- Olfat Gamil Shaker🇪🇬Cairo University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Post-operative pain following root canal therapy remains a prevalent clinical issue, especially in cases of symptomatic apical periodontitis, where inflammatory mediators such as interleukin-8 (IL-8) and substance P are critically involved in the pathophysiology. This study aimed to assess and compare the efficacy of LLLT and Calcium Hydroxide (CH) as intracanal medication in alleviating post-operative pain, percussion sensitivity, and in reducing the levels of IL-8 and substance P in periapical exudate one week after root canal instrumentation in patients with symptomatic apical periodontitis.
Methodology
This comparative, parallel-design randomized clinical trial evaluated the effectiveness of low-level laser therapy (LLLT) versus Calcium Hydroxide in managing post-operative pain in 48 patients with symptomatic apical periodontitis. Patients aged 20-55 with mature, single-canalled permanent teeth were randomly assigned (1:1) to either treatment group using computer-generated randomization with concealed allocation. Root canal therapy was performed over two visits, with pre- and post-operative pain and percussion sensitivity recorded at different time intervals. Periapical fluid samples were collected immediately post-instrumentation (PS-1) and after one week (PS-2) to quantify substance P and IL-8 using ELISA. Blinding was maintained for the molecular biologist and the statistician. Data were analyzed using SPSS v25.0.
Results
Two patients were lost to follow-up; therefore, 46 patients were included in the analysis. Statistical analysis revealed no significant differences between the LLLT and Calcium Hydroxide groups in terms of postoperative pain at any assessed time point, nor in percussion pain at 1-week post-instrumentation (p > 0.05). Furthermore, the reduction in substance P and IL-8 concentrations between PS-1 and PS-2 samples did not differ significantly between groups (p = 0.123 and p = 0.385, respectively).
Conclusion
Within the Limitations of this study, it may be concluded that LLLT may be considered a viable single-visit treatment option and an effective alternative to Calcium Hydroxide for the management of Symptomatic Apical Periodontitis, as both demonstrated comparable clinical pain relief and biochemical modulation of IL-8 and Substance P.
Trial registration number
NCT04594317 on Clinicaltrials.gov on 13th of oct. 2020.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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