Sulforaphane reprograms the metabolomic landscape of chronic kidney disease: insights from NMR-based metabolomics
Ribeiro M, Cardozo LFMF, Borges NA, Manhães L, Pereira AD, Sforça ML, Rodrigues da Silva GH, Mafra D
Food & function · 0 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Según 3 financiadores declarados.
Publicación
- Publicado
- 2026-01-01 · Food Funct · vol. 17 · número 12 · págs. 5538–5547
- Editorial
- Royal Society of Chemistry
- Citado
- 1 cita · más que el 86% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Metabolomics and Mass Spectrometry Studies · Dialysis and Renal Disease Management
- Palabras clave
- sulforaphane, chronic kidney disease, metabolomics, oxidative stress, inflammation, heme oxygenase-1, Nrf2, amino acid metabolism, insulin resistance, mitochondrial function, lipid metabolism, nutraceuticals, dietary supplementation, glycerol, methanol
- MeSH
- humans, isothiocyanates, sulfoxides, magnetic resonance spectroscopy, oxidative stress, aged, middle aged, female, male, nf-e2-related factor 2, renal insufficiency, chronic, metabolomics
8 autores
- Marcia Maria Ribeiro🇧🇷Universidade Federal do Rio de Janeiro; Instituto de Biofísica Carlos Chagas Filho
- L. Cardozo🇧🇷Universidade Federal Fluminense
- Natália Alvarenga Borges🇧🇷Universidade do Estado do Rio de Janeiro
- Larissa Ribeiro Manhães🇧🇷Universidade do Estado do Rio de Janeiro
- Aline D. Pereira🇧🇷Universidade do Estado do Rio de Janeiro
- Mauricio Luis Sforça🇧🇷Brazilian Center for Research in Energy and Materials; Brazilian Biosciences National Laboratory
- Gustavo H. Rodrigues da Silva🇧🇷Brazilian Center for Research in Energy and Materials; Brazilian Biosciences National Laboratory
- Denise Mafra🇧🇷 · autor de correspondenciaUniversidade Federal do Rio de Janeiro; Universidade Federal Fluminense; Instituto de Biofísica Carlos Chagas Filho
Resumen
El texto original del estudio, en el idioma en que se publicó.
Chronic kidney disease (CKD) is characterized by systemic metabolic disturbances and oxidative stress. Nutritional interventions using bioactive compounds such as sulforaphane (SFN) may represent a promising adjuvant strategy to attenuate these alterations. This study evaluated the effects of SFN supplementation on the untargeted metabolomic profile of non-dialysis CKD patients. A randomized, placebo-controlled clinical trial was conducted in 14 patients with CKD stages 3-5 who received either 400 µg per day of SFN or placebo for 30 days. Serum samples were analyzed using proton nuclear magnetic resonance (1H NMR) spectroscopy to identify metabolomic alterations and their correlations with markers of oxidative stress, inflammation, and gene expression. SFN supplementation tended to reduce 2-hydroxyisovalerate and glycerol levels, metabolites associated with insulin resistance and oxidative stress, and attenuated methanol elevation. Correlations were identified between heme oxygenase-1 (HO-1) and several amino acids, and between NRF2 and glycerol, suggesting an interplay between amino acid metabolism and antioxidant defense. Overall, SFN modulated the metabolomic profile of CKD patients, particularly metabolites related to mitochondrial function, lipid metabolism, and oxidative balance. These findings demonstrate that NMR-based metabolomics is a powerful non-invasive approach for elucidating the molecular effects of nutritional therapies in CKD and support SFN as a potential nutraceutical strategy in renal care.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.