Exploring the impact of intermittent fasting plus time-restricted eating versus calorie restriction on eating behavior, mood, sleep, quality of life in adults with obesity
Teong XT, Liu K, Vincent AD, Liu B, Wittert GA, Hutchison AT, Heilbronn LK
Clinical nutrition (Edinburgh, Scotland) · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Australian Government
- Universidad u hospital
- University of Adelaide
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- National Health and Medical Research Council (1143092)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2026-05-15 · Clin Nutr · vol. 62 · pág. 106686
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 33% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Eating Disorders and Behaviors · Nutrition, Health and Food Behavior
- Palabras clave
- intermittent fasting, time-restricted eating, caloric restriction, obesity, weight loss, dietary habits, disinhibition, dietary restraint, hunger, mood, sleep, quality of life, dietary adherence, mediation analysis
- MeSH
- humans, obesity, weight loss, caloric restriction, fasting, feeding behavior, affect, sleep, quality of life, adult, aged, middle aged, female, male, intermittent fasting
7 autores
- Xiao Tong Teong🇦🇺South Australian Health and Medical Research Institute; Adelaide University; The University of Adelaide
- Kai Liu🇦🇺South Australian Health and Medical Research Institute; Adelaide University; The University of Adelaide
- Andrew D. Vincent🇦🇺Adelaide University; The University of Adelaide
- Bo Liu🇦🇺South Australian Health and Medical Research Institute; Adelaide University; The University of Adelaide
- Gary Wittert🇦🇺South Australian Health and Medical Research Institute; Adelaide University; The University of Adelaide
- Amy T. Hutchison🇦🇺South Australian Health and Medical Research Institute; Adelaide University; The University of Adelaide
- Leonie Kaye Heilbronn🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; Adelaide University; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Psychological and behavioural effects influence diet adherence and mediate the effectiveness of lifestyle interventions but are poorly studied with intermittent fasting approaches. Therefore, we compared the effects of intermittent fasting versus calorie restriction on eating behavior, mood, sleep, and quality of life after 6 months and 18 months.
Methods
This is an exploratory analysis of a randomized controlled trial with 6-month intervention and 12-month follow-up. Adults (n = 209, 57% female; 58 ± 10 years, 34.8 ± 4.7 kg/m2) with obesity were randomized to one of three groups (2:2:1): (i) intermittent fasting plus early time-restricted eating (iTRE, 30% energy requirements between 8am and 12pm followed by 20-h fasting three non-consecutive days, non-restricted on other days), (ii) calorie restriction (CR, 70% energy requirements), (iii) standard care (SC). Both iTRE and CR groups received nutritional support biweekly, whereas SC was provided healthy guidelines at baseline only. Eating behaviors, mood, sleep, mood and quality of life were assessed using validated questionnaires at month 0, 2, 6, 18. Mediation analysis was performed to examine the relationship between eating behavior and weight loss at 2 and 6 months.
Results
Greater weight loss was observed in iTRE and CR versus SC at month 2 and 6. However, greater increases in dietary restraint were observed in CR versus iTRE and SC at month 2, 6 and 18. Greater reductions in disinhibition and feelings of hunger were also observed in CR versus iTRE and SC at month 6. There was no detectable mediation effect of change in dietary restraint on weight loss, but disinhibition appeared to mediate the effect on weight loss in CR, accounting for 15% of the total treatment effect.
Conclusion
Both intermittent fasting and CR effectively induce weight loss, but they potentially act through distinct behavioural pathways, with disinhibition playing a more prominent role in CR.
Clinicaltrials
gov identifier, NCT03689608.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.