Microencapsulated docosahexaenoic acid increases the Omega-3 Index and attenuates the physiological impact of eccentric exercise in physically trained adults: a 12-week double-blind placebo-controlled trial
Anthony R, Macartney MJ, McLennan PL, Elhage A, Sluyter R, Sampson JA, Mitchell TW, Peoples GE
European journal of nutrition · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Wollongong
- Universidad u hospital
- The University of Wollongong
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-05-29 · Eur J Nutr · vol. 65 · número 4
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 33% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Fatty Acid Research and Health · Muscle metabolism and nutrition
- Palabras clave
- docosahexaenoic acid, omega-3 index, eccentric exercise, exercise-induced muscle damage, delayed onset muscle soreness, neuromuscular function, inflammatory cytokines, interleukin-6, TNF-α, IL-10, muscle recovery, dietary supplementation
- MeSH
- muscle, skeletal, humans, inflammation, fatty acids, omega-3, docosahexaenoic acids, cytokines, exercise, double-blind method, dietary supplements, adult, female, male, young adult, myalgia, post-exercise recovery
8 autores
- Ryan Anthony🇦🇺University of Wollongong
- Michael J. Macartney🇦🇺University of Wollongong
- Peter L. McLennan🇦🇺University of Wollongong
- Amal Elhage🇦🇺University of Wollongong
- Ronald Sluyter🇦🇺University of Wollongong
- John Andrew Sampson🇦🇺University of Wollongong
- Todd W. Mitchell🇦🇺University of Wollongong
- Gregory E. Peoples🇦🇺 · autor de correspondenciaUniversity of Wollongong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This study investigated the effects of docosahexaenoic acid (DHA) supplementation on delayed onset muscle soreness (DOMS), physical function, and inflammation following eccentric exercise-induced muscle damage in physically trained male and female adults (training ≥ 5d/wk).
Methods
Thirty-eight participants (12 Control, 26 DHA) completed a 12-week double-blind, placebo-controlled matched-pair trial. The Control group received high-oleic acid tablets. The DHA group received 715 mg/d of microencapsulated DHA tablets. Participants performed eccentric cycling at weeks 0 and 12, with assessments conducted pre-exercise, 0-h, 24-h, and 48-h post-exercise. The primary outcomes were DOMS (visual analogue scale) and the Omega-3 Index (O3I) (estimated by finger-stick dry blood spot). Secondary outcomes included neuromuscular function and inflammatory cytokines.
Results
O3I was not different between groups at week 0 but was elevated in the DHA group (∆2.43%, [95% CI; 2.10, 2.77], P < 0.001) and between Control at week 12 (P < 0.001). DOMS was lower at 24-h and 48-h post-exercise in the DHA group and between Control at week 12 (P < 0.01). At week 12, jump height and peak vertical force improved at 48-h post-exercise in the DHA group (P < 0.05), resulting in moderate (d = 0.60) and small (d = 0.32) effect sizes for 48-h post-exercise area under the curve (AUC) between groups, respectively. There were interaction effects for 48-h post-exercise AUC of IL-6 (P = 0.049), TNF-α (P = 0.010), and IL-10 (P = 0.026).
Conclusion
A dietary achievable dose of DHA elevated the O3I and reduced DOMS in physically trained adults. These outcomes support protracted intake of DHA to attenuate the physiological impact of eccentric exercise and promote recovery.
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