Effects of combining exercise with a 16:8 time-restricted eating protocol on body composition and glucose-lipid metabolism in adults: a systematic review and meta-analysis
Liu H, Hu G, Ma X
Frontiers in nutrition · 0 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-05-14 · Front Nutr · vol. 13 · pág. 1816555
- Editorial
- Frontiers Media
- Citado
- 0 citas · más que el 23% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Physical Activity and Health
- Palabras clave
- time-restricted eating, 16:8 fasting, physical activity, body composition, body weight, fat mass, glucose-lipid metabolism, triglycerides, LDL cholesterol, aerobic exercise, sex differences, metabolic health
3 autores
- Hengru Liu🇨🇳Chengdu Sport University
- Guidan Hu🇨🇳Chengdu Sport University
- Xiujie Ma🇨🇳🇬🇧 · autor de correspondenciaChengdu Sport University; Cardiff University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Time-restricted eating (TRE) has emerged as a promising nutritional strategy for improving metabolic health, yet its additive benefits when combined with structured exercise remain unclear.
Objective
This systematic review and meta-analysis evaluated the effects of exercise combined with a 16:8 TRE protocol on body composition and glucose-lipid metabolism in adults.
Methods
Following PRISMA guidelines and PROSPERO registration (CRD420251240058), eight electronic databases were searched through August 2025 for randomized and randomized crossover trials comparing exercise plus 16:8 TRE with exercise alone. Three reviewers independently performed study selection, data extraction, risk-of-bias assessment (ROB 2), and GRADE evaluation. Random-effects meta-analyses were conducted using R software. Subgroup analyses and meta-regression explored potential moderators.
Results
Fifteen trials involving 511 participants were included. Compared with exercise alone, the combined intervention significantly reduced body weight (MD - 1.44 kg, 95% CI - 2.74 to -0.13) and fat mass (MD - 1.04 kg, 95% CI - 1.95 to -0.13). Significant improvements were also observed in triglycerides (SMD - 0.25, 95% CI - 0.45 to -0.06) and LDL cholesterol (SMD - 0.22, 95% CI - 0.37 to -0.08), while other body composition and glycemic markers showed no significant changes. Greater reductions in body weight and fat mass were observed when TRE was combined with aerobic exercise, and LDL-C reductions were more pronounced in men. Sensitivity analyses confirmed result robustness with minimal publication bias.
Conclusion
Exercise combined with a 16:8 TRE protocol may confer small additional short-term benefits for body weight, fat mass, and selected lipid markers beyond exercise alone. However, the evidence base is limited by the small number of studies, modest sample sizes, and imbalance in participant characteristics across sex and metabolic status. These findings should therefore be interpreted cautiously.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.