The effects of intermittent fasting on BMI, fasting blood glucose, and blood pressure in women with overweight or obesity: a systematic review and meta-analysis with dose-response relationships
He H, Qin Z, Liu K, Wang Z, Wang J
Frontiers in nutrition · 0 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-05-14 · Front Nutr · vol. 13 · pág. 1818813
- Editorial
- Frontiers Media
- Citado
- 0 citas · más que el 23% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 68 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Obesity, Physical Activity, Diet
- Palabras clave
- intermittent fasting, obesity, overweight, women, body mass index, fasting blood glucose, blood pressure, dose-response relationship, weight loss, glycemic control, moderators, heterogeneity
5 autores
- Haoran He🇨🇳Capital University of Physical Education and Sports
- Zhikai Qin🇨🇳Fujian Normal University
- Kuiliang Liu🇨🇳Capital University of Physical Education and Sports
- Zhitian Wang
- Jiaoqin Wang🇨🇳 · autor de correspondenciaCapital University of Physical Education and Sports
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study aimed to assess the effects of intermittent fasting (IF) on prespecified clinically relevant outcomes, including BMI, fasting blood glucose (FBG), and blood pressure, in women with overweight or obesity, and to explore the dose-response relationship and moderating factors of the intervention.
Methods
Following PRISMA guidelines, we systematically searched PubMed, Web of Science, PsycINFO, and the Cochrane Library (up to August 1, 2025) for eligible randomized controlled trials (RCTs). Twenty-two studies involving 1,287 women with overweight or obesity were included. Mean differences (MD) were pooled using a restricted maximum likelihood random-effects model (REML). Heterogeneity was evaluated via I 2 and Q tests, while publication bias was assessed using sensitivity analyses, Egger's regression, and the trim-and-fill method. Subgroup analyses, meta-regression, and nonlinear dose-response models were used to identify moderators.
Results
IF significantly reduced BMI in the final BMI model after exclusion of one influential study (MD = -0.41, 95% CI: -0.81 to-0.02, P = 0.0396) and FBG (MD = -2.18, 95% CI:-3.20 to-1.16, P I 2 = 80.2%). Subgroup analyses suggested variability across intervention characteristics and participant strata, but these findings should be interpreted cautiously because several subgroup estimates were based on limited evidence. Dose-response analysis suggested a relatively favorable modeled frequency around twice weekly, with effects remaining relatively stable across 1,285-2,895 total intervention hours.
Conclusion
IF may improve BMI and FBG in women with overweight or obesity, whereas no significant effects were observed for blood pressure outcomes. The dose-response findings suggest potentially favorable intervention patterns, but these should be interpreted cautiously because of heterogeneity across studies, variation in intervention and comparator conditions, possible co-interventions, and the limited certainty of the available evidence. Further well-designed trials are needed to confirm these findings and refine practical recommendations.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD420251178671, identifier: CRD420251178671.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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