Association of combined ultra-processed food intake (ultra-processed dietary pattern) with cognitive function impairment: a meta-analysis of prospective cohort studies
Zhang S, Zhuang X, Jiang Y, Wang H, He X, Zhang Q, Ji X, Lu Y, Li F
Journal of neurology · 1 cita
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-06-01 · J Neurol · vol. 273 · número 6
- Editorial
- Springer Science+Business Media
- Citado
- 1 cita · más que el 90% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Health, Technology, Consumer Behavior
- Palabras clave
- Prospective cohort study, Context (archaeology), Cognition, Limiting, Association (psychology), Cohort study, Hazard ratio, Cohort, Food intake, Meta-analysis
- MeSH
- humans, diet, cohort studies, prospective studies, fast foods, cognitive dysfunction, food, processed
9 autores
- Shipeng Zhang🇨🇳Chengdu University of Traditional Chinese Medicine
- Xiulian Zhuang🇨🇳Chengdu University of Traditional Chinese Medicine
- Yanjie Jiang🇨🇳Nanjing University of Chinese Medicine
- Hanyu Wang🇨🇳Chengdu University of Traditional Chinese Medicine
- Xingyi He🇨🇳Guangzhou University of Chinese Medicine
- Qinxiu Zhang🇨🇳Chengdu University of Traditional Chinese Medicine
- Xiaoli Ji🇨🇳 · autor de correspondenciaChengdu University of Traditional Chinese Medicine
- Yan Lü🇨🇳 · autor de correspondenciaNanjing University of Chinese Medicine
- Fu Li🇨🇳 · autor de correspondenciaChengdu University of Traditional Chinese Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous studies on ultra-processed foods (UPF) and cognitive impairment often isolated UPF from overall dietary patterns, limiting real-world interpretation.
Methods
We systematically searched PubMed, Embase, Web of Science, and Cochrane Library up to April 2026 for prospective cohort studies assessing total UPF intake (defined by NOVA) and risk of cognitive impairment (including cognitive dysfunction, dementia, and Alzheimer's disease). A random-effects model was used to pool adjusted hazard ratios (HRs) comparing highest versus lowest UPF consumption.
Results
Eight cohort studies (total > 250,000 participants) were included. High combined UPF intake was associated with a 14% higher risk of cognitive impairment (pooled HR = 1.14, 95%CI 1.04-1.25, I2 = 64.6%). The association was more pronounced in participants aged 60 years. Large studies (> 10,000) and longer follow-up (> 15 years) showed stable estimates with lower heterogeneity.
Conclusion
Higher consumption of UPF within a ultra-processed dietary context is positively associated with cognitive impairment risk, particularly among middle-aged adults. These findings support dietary guidelines that recommend limiting UPF intake.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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