Time-Restricted Eating Promotes Weight Loss and Favorable Changes in Adipose in Obesity: The TREAD Randomized Control Trial
Wilkinson MJ, Padilla E, Wang Y, Raygani S, Manoogian ENC, Laing K, Tong K, Liu L, Van D, Nguyen J, Saltiel AR, Reilly SM, O'Neal M, Panda S, Majithia AR, Taub PR
Obesity (Silver Spring, Md.) · 0 citas
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- University of California, San Diego
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- National Institute of Diabetes and Digestive and Kidney Diseases (DK063491); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK139356); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK063491); National Heart, Lung, and Blood Institute (R01HL159760); National Institutes of Health (NIH R01DK124422); National Institutes of Health (1r01dk118278-01); National Institutes of Health (1r01dk139356-01); University of California, San Diego (P30DK063491); University of California, San Diego (DK063491); University of California, San Diego (KL2TR001444); Georgia Clinical and Translational Science Alliance (UL1TR001442); National Institute of Diabetes and Digestive and Kidney Diseases (UL1TR001442); University of California, San Diego (UL1TR001442); National Institutes of Health (KL2TR001444); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK118278); National Institutes of Health (P30-DK063491); National Institutes of Health (DK-063491); National Institutes of Health (UL1 TR001442.); National Institutes of Health (NIH R01DK118278); National Institutes of Health (NIH KL2TR001444)
Según 9 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-02 · Obesity (Silver Spring) · vol. 34 · número 7 · págs. 1395–1408
- Editorial
- Wiley
- Citado
- 1 cita · más que el 93% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Adipokines, Inflammation, and Metabolic Diseases · Adipose Tissue and Metabolism
- Palabras clave
- time-restricted eating, weight loss, adipose tissue, subcutaneous abdominal fat, gene expression, pro-inflammatory genes, cardiometabolic health, body composition, nutrition counseling, eating window
- MeSH
- adipose tissue, humans, obesity, weight loss, body mass index, fasting, adult, aged, middle aged, female, male, intermittent fasting
16 autores
- Michael J. Wilkinson🇺🇸 · autor de correspondenciaUniversity of California San Diego
- Erika Padilla🇺🇸University of California San Diego
- Yuqi Wang🇺🇸University of California San Diego
- Sawye Raygani🇺🇸University of California San Diego
- Emily N. C. Manoogian🇺🇸Salk Institute for Biological Studies
- Kyla L. Laing🇺🇸Salk Institute for Biological Studies
- Khang Tong🇺🇸University of California San Diego
- Lu Liu🇺🇸University of California San Diego
- David T. Van🇺🇸University of California San Diego
- Justina P. Nguyen🇺🇸University of California San Diego
- Alan R. Saltiel🇺🇸University of California San Diego
- Shannon M. Reilly🇺🇸University of California San Diego; Weill Cornell Medicine
- Monica A. O'Neal🇺🇸Salk Institute for Biological Studies
- Satchidananda Panda🇺🇸Salk Institute for Biological Studies
- Amit R. Majithia🇺🇸University of California San Diego
- Pam R. Taub🇺🇸University of California San Diego
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Examine time-restricted eating (TRE) as a strategy to promote weight loss and cardiometabolic health in adults with obesity.
Methods
TRE in obesity and ADipose Tissue (TREAD) was a single-center 12-week RCT, involving 1:1 randomization to 10-h TRE versus standard of care (SOC) in adults with obesity (BMI 30-50 kg/m2) without diabetes and baseline eating window ≥ 14 h/day. The primary endpoint was change in weight (kg). Exploratory RNA-seq in subcutaneous abdominal adipose tissue was performed in a subgroup of participants.
Results
A total of 61 participants were randomized, and 52 (26 TRE, 26 SOC) completed the study. Mean ± SD age was 55 ± 12.1 years, n = 35 were (58%) women, n = 35 were non-Hispanic White (58%), and BMI was 35.5 ± 4.8 kg/m2. With TRE, the mean total reduction in weight from baseline to end of study was -4.59 kg (95% CI -5.51, -3.67) (-4.6%) versus -1.68 kg (95% CI -2.59, -0.77) (-1.7%) with SOC (between-group difference -2.91 kg [-4.21, -1.60]) (p < 0.001), primarily through loss of body fat. Downregulation of proinflammatory genes was observed in adipose tissue during TRE.
Conclusions
In adults with obesity, compared with SOC dietary counseling alone, TRE promotes weight loss, healthier body composition, and, in exploratory analyses, reduction in adipose tissue proinflammatory gene expression.
Trial registration
ClinicalTrials.gov identifier: NCT04916730.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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