Efficacy of intermittent fasting on blood glucose and weight in type 2 diabetes and prediabetes: A comparison with ad libitum and continuous energy restriction diets
Chen J, Liu P, Wang M, Yan X, Li J, Guo J
Asia Pacific journal of clinical nutrition · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ningxia Natural Science Foundation
- Gobierno
- National Natural Science Foundation of China
Según 2 financiadores declarados.
Publicación
- Publicado
- 2026-06-01 · Asia Pac J Clin Nutr · vol. 35 · número 3 · págs. 398–411
- Editorial
- National Institutes of Health
- Citado
- 0 citas · más que el 41% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dietary Effects on Health · Diabetes Management and Research · Diet and metabolism studies
- Palabras clave
- intermittent fasting, type 2 diabetes, prediabetes, HbA1c, fasting blood glucose, body weight, body mass index, ad libitum feeding, weight loss, dropout rates, glycemic control, diet comparison, heterogeneity bias, publication bias, small sample bias, small study size bias, risk of bias
- MeSH
- humans, diabetes mellitus, type 2, prediabetic state, body weight, blood glucose, body mass index, caloric restriction, diet, reducing, randomized controlled trials as topic, glycated hemoglobin, intermittent fasting
6 autores
- Jianmei Chen🇨🇳Ningxia Medical University
- Pengjuan Liu🇨🇳Ningxia Medical University
- Muhan Wang🇨🇳Ningxia Medical University
- Xiaowen Yan🇨🇳Ningxia Medical University
- Jiangping Li🇨🇳Ningxia Medical University
- Jianrong Guo🇨🇳Ningxia Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
This study aimed to evaluate the effects of intermittent fasting (IF) on glycated hemoglobin (HbA1c), fasting blood glucose (FBG), body weight (BW), and body mass index (BMI) in pa-tients with type 2 diabetes mellitus (T2DM) and prediabetes.
Methods and study design
A systematic search of PubMed, Cochrane Library, Embase, Scopus, and Web of Science was conducted for randomized controlled trials on IF in T2DM and prediabetes published before September 30, 2025. Meta-analysis was performed using RevMan 5.3 and Stata 17.0.
Results
Fourteen studies (sixteen arms), involving 899 patients, were included. Four studies (five arms) compared IF with ad libitum diet (316 patients), and ten studies (eleven arms) compared IF with continuous energy restriction diets (CERD) (583 patients). Meta-analysis showed that IF was more effective than the ad libitum diet in reducing HbA1c, BW, BMI and FBG (Standard-ized Mean Difference (SMD) (Hedges's g) -0.64, 95% Confidence Interval (CI) -1.04, -0.24; p <0.05), (SMD (Hedges's g) -0.30, 95% CI -0.55, -0.05; p <0.05), (SMD (Hedges's g) -0.26, 95% CI -0.51, 0.00; p = 0.05), (SMD (Hedges's g) -0.39, 95% CI -0.64 to -0.15; p <0.05). IF demonstrated effects similar to CERD (p <0.05) in terms of HbA1c, BW, BMI, and FBG. Among 14 studies, dropout rates were 21.5% (IF), 26.2% (CERD), and 15.9% (ad libitum). CERD showed a significantly higher dropout rate than ad libitum, whereas no significant differences were observed between IF and CERD or between IF and ad libitum.
Conclusions
Intermit-tent fasting is a effective dietary approach for patients with T2DM and prediabetes.
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