Financiado en parte por U.S. Highbush Blueberry Council, US Highbush Blueberry Council
Effects of a 24-week intervention with freeze-dried blueberries on brain health in older adults: A randomized double-blind, placebo-controlled trial
Guardino ET, Gabriel O, Mukamal KJ, Djousse L
Clinical nutrition ESPEN · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Grupo de la industria
- US Highbush Blueberry Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 2026-06-06 · Clin Nutr ESPEN · vol. 74 · pág. 103377
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 36% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Palabras clave
- dietary intervention, brain health, phosphorylated tau, neurofilament light chain, glial fibrillary acidic protein, free fatty acids, blood pressure, cognitive function, older adults, neurodegeneration biomarkers, functional foods, cognitive aging, dietary polyphenols, dietary fiber, dietary protein, dietary fiber to protein ratio
- MeSH
- brain, humans, fruit, glial fibrillary acidic protein, neurofilament proteins, fatty acids, nonesterified, tau proteins, freeze drying, double-blind method, cognition, phosphorylation, blood pressure, aged, female, male, biomarkers, blueberry plants
4 autores
- Eric T. Guardino🇺🇸Mass General Brigham
- Olivia Gabriel🇺🇸Mass General Brigham
- Kenneth Jay Mukamal🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Luc Djoussé🇺🇸 · autor de correspondenciaHarvard University; Mass General Brigham
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Clinical trials using freeze-dried blueberries on measures of cognition or serum brain biomarkers are sparse or lacking. Our primary aim was to test whether an intervention with freeze-dried blueberries reduces serum phosphorylated tau (p-tau181) and neurofilament light (NFL). Secondary outcomes included serum non-esterified fatty acids, glial fibrillary acidic protein (GFAP), blood pressure, and computer-based cognitive tests.
Methods
This was a randomized double-blind trial where 57 cognitively healthy subjects were assigned either 20 g/d of freeze-dried blueberry powder or matching placebo for 24 weeks. We collected blood samples for biomarker measurements and administered cognitive tests during each of the four study visits spaced by 8 weeks.
Results
Mean (SD) age at baseline was 73.5 (6.6) years among 28 subjects randomized to blueberry powder and 73.3 (5.2) years among 29 subjects assigned to placebo. There was no statistically significant difference in change over time in serum p-tau181 [i.e., baseline and 24-week adjusted mean (95% CI) were 38.5 (21.3-55.7) and 38.9 (21.7-56.1) pg/mL in the placebo group versus 47.2 (28.9-65.5) and 54.7 (36.3-73.0) pg/mL in the blueberry group] (p for interaction between biomarker and time: 0.10)] or serum NFL [i.e., corresponding values were 26.2 (18.2-34.1) and 25.0 (17.1-33.0) pg/mL in the placebo group and 26.6 (18.2-35.0) and 28.0 (19.5-36.5) pg/mL in the blueberry group, p for interaction 0.58]. In secondary aims, blueberry intervention reduced diastolic blood pressure (p interaction with time 0.015) but there was no effect on systolic blood pressure, cognitive tests, and other biomarkers.
Conclusion
A 24-week intervention with freeze-dried blueberries had no effect on serum p-tau181 and serum NFL in older adults.
Trial registration
NCT05764824, https://clinicaltrials.gov/study/NCT05764824.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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