Clinical Efficacy of Vitamin D Supplements for the Treatment of Anemia in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Wanyan X, Xu J
Hemodialysis international. International Symposium on Home Hemodialysis · 1 cita
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-07 · Hemodial Int · vol. 30 · número 3 · págs. 478–485
- Editorial
- Wiley
- Citado
- 1 cita · más que el 91% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Erythropoietin and Anemia Treatment · Iron Metabolism and Disorders
- Palabras clave
- Anemia, Randomized controlled trial, Kidney disease, Inclusion and exclusion criteria, Vitamin D and neurology, Meta-analysis, Clinical efficacy, Cochrane Library
- MeSH
- humans, anemia, vitamin d, treatment outcome, dietary supplements, female, male, renal insufficiency, chronic
2 autores
- Xiaodong Wanyan🇨🇳First Affiliated Hospital of Henan University of Science and Technology
- Jiayun Xu🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Henan University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To conduct a meta-analysis of clinical randomized controlled studies related to vitamin D supplements for the treatment of anemia in patients with chronic kidney disease (CKD), to evaluate the clinical efficacy of vitamin D supplements for CKD patients complicated with anemia.
Methods
A literature review of the published literature in both English and Chinese was searched from the Cochrane Library, PubMed, Web of Science, CNKI and Wanfang Data that were published from the inception date to January 2018. Randomized controlled trials (RCTs) eligible for the inclusion and exclusion criteria were selected. The quality of eligible studies was assessed by the Cochrane Risk of Bias tool. Meta-analysis was performed by using Revman 5.3 software.
Results
A total of 12 RCTs comprising 779 patients were included in this meta-analysis, including 383 patients in the experimental group (with vitamin D supplementation) and 396 patients in the control group (without vitamin D supplementation). Meta-analysis showed that vitamin D supplements could significantly increase the hemoglobin (p < 0.01, SMD = 1.24, 95% CI: 1.02-1.45) and lower the dosage of erythropoietin required (p < 0.01, SMD = -0.76, 95% CI: -1.09 to -0.43).
Conclusion
Use of vitamin D supplements can significantly elevate the hemoglobin concentration and reduce the dosage of erythropoietin. However, these findings remain to be validated by large-scale, multi-center, prospective RCTs.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.